The arcuate fasciculus in auditory-verbal hallucinations: Ameta-analysis of diffusion-tensor-imaging studies

Pierre A. Geoffroy, Josselin Houenou, Alain Duhamel, Ali Amad, Antoin D. De Weijer, Branislava Curcic-Blake, David E. J. Linden, Pierre Thomas, Renaud Jardri*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

54 Citations (Scopus)

Abstract

Auditory-verbal hallucinations (AVHs) are associated with an impaired connectivity of large-scale networks. To examine the relationship between white-matter integrity and AVHs, we conducted a meta-analysis of diffusion-tensor-imaging studies that compared patients with schizophrenia and AVHs with matched healthy controls (HCs). Five studies were retained gathering 256 DTI data points, divided into AVHs (n=106) and HCs (n=150). The meta-analysis demonstrated a reduced fractional anisotropy in the left Arcuate Fasciculus (AF) of hallucinators (hg= -0.42; CI[-0.69,-0.16]; p<10(-3)). The current meta-analysis confirmed disruptions of white matter integrity in the left AF bundle of schizophrenia patients with AVHs.

Original languageEnglish
Pages (from-to)234-237
Number of pages4
JournalSchizophrenia Research
Volume159
Issue number1
DOIs
Publication statusPublished - Oct-2014

Keywords

  • Auditory-Verbal Hallucinations (AVH)
  • Diffusion-Weighted Imaging (DWI)
  • Arcuate Fasciculus (AF)
  • Connectivity
  • Meta-analysis
  • Sensitivity exclusion analysis
  • SCHIZOPHRENIA
  • CONNECTIVITY
  • METAANALYSIS
  • INTEGRITY
  • PATHWAYS
  • VOICES

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