The association between active tumor volume, total lesion glycolysis and levels of S-100B and LDH in stage IV melanoma patients

E A Deckers*, S Kruijff*, A H Brouwers, K van der Steen, H J Hoekstra, J F Thompson, David Vállez García, K P Wevers

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Introduction: The Standardized Uptake Value (SUV) in single lesions on F-18-FDG PET/CT scans and serum S-100B concentrations are inversely associated with disease-free survival in stage IV melanoma. The aim of this study was to assess the association between biomarkers (S-100B, LDH) and the PET-derived metrics SUVmean/max, metabolic active tumor volume (MATV), and total lesion glycolysis (TLG) in stage IV melanoma in order to understand what these biomarkers reflect and their possible utility for follow-up.

Methods: In 52 stage IV patients the association between PET-derived metrics and the biomarkers S-100B and LDH was assessed and the impact on survival analyzed.

Results: S-100B was elevated (>0.15 mu g/l) in 37 patients (71%), LDH in 11 (21%). There was a correlation between S-100B and LDH (R-2 = 0.19). S-100B was correlated to both MATV (R-2 = 0.375) and TLG (R-2 = 0.352), but LDH was not. Higher MATV and TLG levels were found in patients with elevated S-100B (p <0.001) and also in patients with elevated LDH (>250 U/l) (p <0.001). There was no association between the biomarkers and SUVmean/max. Survival analysis indicated that LDH was the only predictor of melanoma-specific survival.

Conclusion: In newly diagnosed stage IV melanoma patients S-100B correlates with F-18-FDG PET/CT derived MATV and TLG in contrast to LDH, is more often elevated than LDH (71% vs. 21%) and seems to be a better predictor of disease load and disease progression. However, elevated LDH is the only predictor for survival. The biomarkers, S-100B and LDH appear to describe different aspects of the extent of metastatic disease and of tumornecrosis. (C) 2020 The Authors. Published by Elsevier Ltd.

Original languageEnglish
Pages (from-to)2147-2153
Number of pages7
JournalEuropean Journal of Surgical Oncology
Volume46
Issue number11
Early online date27-Jul-2020
DOIs
Publication statusPublished - Nov-2020

Keywords

  • Melanoma
  • PET
  • Biomarkers
  • S-100B
  • LDH
  • Staging
  • FDG-PET/CT
  • LACTATE-DEHYDROGENASE
  • MALIGNANT-MELANOMA
  • SERUM S-100B
  • SURVIVAL
  • GUIDELINES
  • IPILIMUMAB
  • DIAGNOSIS
  • PROTEIN
  • ASSAYS

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