The Association of Albuminuria With Tubular Reabsorption of Uric Acid: Results From a General Population Cohort

Lieneke Scheven, Michel M. Joosten, Paul E. de Jong, Stephan J. L. Bakker, Ron T. Gansevoort*, PREVEND Study Group

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)
280 Downloads (Pure)

Abstract

Background-Elevated albuminuria as well as an increased serum uric acid concentration is associated with poor cardiovascular outcome. We questioned whether these 2 variables (albuminuria and serum uric concentration) may be interrelated via tubular uric acid reabsorption.

Methods and Results-Included were 7688 participants of the PREVEND Study, an observational, general population-based cohort study. Linear regression analyses were used to test associations of baseline albuminuria with baseline serum uric acid concentration and tubular uric acid reabsorption (calculated as [100-fractional uric acid excretion]%). Cox regression analyses were used to study the association of baseline serum uric acid and albuminuria with incident cardiovascular morbidity and mortality. In cross-sectional analyses, albuminuria was associated positively with serum uric acid concentration, both crude and after adjustment for potential confounders (both P

Conclusions-Albuminuria is strongly associated with tubular uric acid reabsorption, and consequently with serum uric acid concentration. This phenomenon may explain in part why albuminuria is associated with cardiovascular outcome.

Original languageEnglish
Article number000613
Number of pages11
JournalJournal of the American Heart Association
Volume3
Issue number2
DOIs
Publication statusPublished - Apr-2014

Keywords

  • albuminuria
  • cardiovascular outcome
  • tubular reabsorption
  • uric acid
  • GLOMERULAR-FILTRATION-RATE
  • DIABETES-MELLITUS
  • SODIUM-INTAKE
  • MICROALBUMINURIA
  • HYPERURICEMIA
  • EXCRETION
  • RISK
  • HYPERTENSION
  • METAANALYSIS
  • EXPRESSION

Cite this