The automatic optimization of separations in high-performance liquid chromatography

HJG Debets*, JW Weyland, DA Doornbos

*Corresponding author for this work

    Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

    18 Citations (Scopus)

    Abstract

    Various quality criteria for chromatographic separations have been suggested, but none of them seems to be useful in the automatic optimization of separations by high-performance liquid chromatography. A different optimization strategy is considered: mathematical relations between parameters from the chromatogram and the solvent composition are established. By using one or more of these relations, the optimal composition of the liquid phase can be predicted for particular separations.
    Original languageEnglish
    Pages (from-to)259-265
    Number of pages7
    JournalAnalytica Chimica Acta
    Volume150
    Issue number1
    DOIs
    Publication statusPublished - 1983

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