The brain at low temperature: Tau hyperphosphorylation dynamics in hibernation and torpor

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    Mammalian torpor is associated with neuronal tau protein hyperphosphorylation. This process is fully reversed upon rewarming to euthermy. Not much is known about the hyperphosphorylation dynamics during cooling and rewarming to and from torpor. In this study we show that there is a negative relation between brain temperature and the amount of tau hyperphosphorylation in the cortex of Syrian hamsters. This relation was found to be nonlinear: the fastest changes in the hyperphosphorylation state of the tau protein occurred around brain temperatures of 27°C. The amount of hyperphosphorylation did not substantially increase further with the time spent in torpor. In mice, reversible hyperphosphorylation could also be detected during torpor-like hypothermia at 21°C, but was not present during torpor-like hypothermia at an ambient temperature of 30°C. These results suggest that tau hyperphosphorylation is not only passively connected with brain temperature, but is actively regulated. The results argue agai
    Original languageEnglish
    Title of host publicationLiving in a Seasonal World
    Subtitle of host publicationThermoregulatory and Metabolic Adaptations
    EditorsW. Arnold, C. Bieber, E. Millesi, T. Ruf
    Place of PublicationBerling, Heidelberg
    PublisherSpringer Verlag
    Number of pages9
    ISBN (Electronic)9783642286780
    ISBN (Print)9783642286773
    Publication statusPublished - Jan-2012

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