The clinical relevance of assessing advanced glycation endproducts accumulation in diabetes

Robbert Meerwaldt*, Thera Links, Clark Zeebregts, Rene Tio, Jan-Luuk Hillebrands, Andries Smit

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

151 Citations (Scopus)
282 Downloads (Pure)

Abstract

Cardiovascular disease is the major cause of morbidity and mortality associated with diabetes. There is increasing evidence that advanced glycation endproducts (AGEs) play a pivotal role in atherosclerosis, in particular in diabetes. AGE accumulation is a measure of cumulative metabolic and oxidative stress, and may so represent the "metabolic memory". Furthermore, increased AGE accumulation is closely related to the development of cardiovascular complications in diabetes. This review article will focus on the clinical relevance of measuring AGE accumulation in diabetic patients by focusing on AGE formation, AGEs as predictors of long-term complications, and interventions against AGEs.

Original languageEnglish
Article number29
Number of pages8
JournalCardiovascular Diabetology
Volume7
DOIs
Publication statusPublished - 7-Oct-2008

Keywords

  • HUMAN ATHEROSCLEROTIC PLAQUES
  • LOW-DENSITY-LIPOPROTEIN
  • INCREASED SERUM-LEVELS
  • END-PRODUCTS PRECEDES
  • SKIN AUTOFLUORESCENCE
  • OXIDATIVE STRESS
  • RISK-FACTOR
  • ENDOTHELIAL DYSFUNCTION
  • MAILLARD REACTION
  • VASCULAR-DISEASE

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