The clinical relevance of assessing advanced glycation endproducts accumulation in diabetes

Robbert Meerwaldt; Thera Links; Clark Zeebregts; Rene Tio; Jan-Luuk Hillebrands; Andries Smit

doi:10.1186/1475-2840-7-29

The clinical relevance of assessing advanced glycation endproducts accumulation in diabetes

Robbert Meerwaldt^*, Thera Links, Clark Zeebregts, Rene Tio, Jan-Luuk Hillebrands, Andries Smit

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

Cardiovascular disease is the major cause of morbidity and mortality associated with diabetes. There is increasing evidence that advanced glycation endproducts (AGEs) play a pivotal role in atherosclerosis, in particular in diabetes. AGE accumulation is a measure of cumulative metabolic and oxidative stress, and may so represent the "metabolic memory". Furthermore, increased AGE accumulation is closely related to the development of cardiovascular complications in diabetes. This review article will focus on the clinical relevance of measuring AGE accumulation in diabetic patients by focusing on AGE formation, AGEs as predictors of long-term complications, and interventions against AGEs.

Original language	English
Article number	29
Number of pages	8
Journal	Cardiovascular Diabetology
Volume	7
DOIs	https://doi.org/10.1186/1475-2840-7-29
Publication status	Published - 7-Oct-2008

Keywords

HUMAN ATHEROSCLEROTIC PLAQUES
LOW-DENSITY-LIPOPROTEIN
INCREASED SERUM-LEVELS
END-PRODUCTS PRECEDES
SKIN AUTOFLUORESCENCE
OXIDATIVE STRESS
RISK-FACTOR
ENDOTHELIAL DYSFUNCTION
MAILLARD REACTION
VASCULAR-DISEASE

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title = "The clinical relevance of assessing advanced glycation endproducts accumulation in diabetes",

abstract = "Cardiovascular disease is the major cause of morbidity and mortality associated with diabetes. There is increasing evidence that advanced glycation endproducts (AGEs) play a pivotal role in atherosclerosis, in particular in diabetes. AGE accumulation is a measure of cumulative metabolic and oxidative stress, and may so represent the {"}metabolic memory{"}. Furthermore, increased AGE accumulation is closely related to the development of cardiovascular complications in diabetes. This review article will focus on the clinical relevance of measuring AGE accumulation in diabetic patients by focusing on AGE formation, AGEs as predictors of long-term complications, and interventions against AGEs.",

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author = "Robbert Meerwaldt and Thera Links and Clark Zeebregts and Rene Tio and Jan-Luuk Hillebrands and Andries Smit",

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T1 - The clinical relevance of assessing advanced glycation endproducts accumulation in diabetes

AU - Meerwaldt, Robbert

AU - Links, Thera

AU - Zeebregts, Clark

AU - Tio, Rene

AU - Hillebrands, Jan-Luuk

AU - Smit, Andries

PY - 2008/10/7

Y1 - 2008/10/7

N2 - Cardiovascular disease is the major cause of morbidity and mortality associated with diabetes. There is increasing evidence that advanced glycation endproducts (AGEs) play a pivotal role in atherosclerosis, in particular in diabetes. AGE accumulation is a measure of cumulative metabolic and oxidative stress, and may so represent the "metabolic memory". Furthermore, increased AGE accumulation is closely related to the development of cardiovascular complications in diabetes. This review article will focus on the clinical relevance of measuring AGE accumulation in diabetic patients by focusing on AGE formation, AGEs as predictors of long-term complications, and interventions against AGEs.

AB - Cardiovascular disease is the major cause of morbidity and mortality associated with diabetes. There is increasing evidence that advanced glycation endproducts (AGEs) play a pivotal role in atherosclerosis, in particular in diabetes. AGE accumulation is a measure of cumulative metabolic and oxidative stress, and may so represent the "metabolic memory". Furthermore, increased AGE accumulation is closely related to the development of cardiovascular complications in diabetes. This review article will focus on the clinical relevance of measuring AGE accumulation in diabetic patients by focusing on AGE formation, AGEs as predictors of long-term complications, and interventions against AGEs.

KW - HUMAN ATHEROSCLEROTIC PLAQUES

KW - LOW-DENSITY-LIPOPROTEIN

KW - INCREASED SERUM-LEVELS

KW - END-PRODUCTS PRECEDES

KW - SKIN AUTOFLUORESCENCE

KW - OXIDATIVE STRESS

KW - RISK-FACTOR

KW - ENDOTHELIAL DYSFUNCTION

KW - MAILLARD REACTION

KW - VASCULAR-DISEASE

U2 - 10.1186/1475-2840-7-29

DO - 10.1186/1475-2840-7-29

M3 - Review article

SN - 1475-2840

VL - 7

JO - Cardiovascular Diabetology

JF - Cardiovascular Diabetology

M1 - 29

ER -

The clinical relevance of assessing advanced glycation endproducts accumulation in diabetes

Abstract

Keywords

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