The costs of complications and unplanned readmissions after pancreatoduodenectomy for pancreatic and periampullary tumors: Results from a single academic center

Ralph J.A. Linnemann, Bob J.L. Kooijman, Christian S. van der Hilst, Joost Sprakel, Carlijn I. Buis, Schelto Kruijff, Joost M. Klaase*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Background/Objectives: Complications after pancreatoduodenectomy (PD) lead to unplanned readmissions (UR), with a two-to threefold increase in admission costs. In this study, we aimed to create an understanding of the costs of complications and UR in this patient group. Furthermore, we aimed to generate a detailed cost overview that can be used to build a theoretical model to calculate the cost efficacy for prehabilitation. Methods: A retrospective cohort analysis was performed using the Dutch Pancreatic Cancer Audit (DPCA) database of patients who underwent a PD at our institute between 2013 and 2017. The total costs of the index hospital admission and UR related to the PD were collected. Results: Of the 160 patients; 35 patients (22%) had an uncomplicated course; 87 patients (54%) had minor complications, and 38 patients (24%) had severe complications. Median costs for an uncomplicated course were EUR 25.682, and for a complicated course, EUR 32.958 (p = 0.001). The median costs for minor complications were EUR 30.316, and for major complications, EUR 42.664 (p = 0.001). Costs were related to the Comprehensive Complication Index (CCI). The median costs of patients with one or more UR were EUR 41.199. Conclusions: Complications after PD led to a EUR 4.634–EUR 16.982 (18–66%) increase in hospital costs. A UR led to a cost increase of EUR 12.567 (44%). Since hospital costs are directly related to the CCI, reduction in complications will lead to cost-effectiveness.

Original languageEnglish
Article number6271
Number of pages18
Issue number24
Publication statusPublished - 14-Dec-2021


  • Complication
  • Costs
  • Pancreas
  • PPPD
  • Readmission
  • Whipple

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