The differential effects of recombinant brain natriuretic peptide, nitroglycerine and dihydralazine on systemic oxygen delivery and gastric mucosal microvascular oxygenation in dogs*

L. A. Schwarte, I. Schwartges, T. W. L. Scheeren*, P. Schober, O. Picker

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Abstract

Brain natriuretic peptide has vasodilatory properties and may thus increase splanchnic perfusion and oxygenation. We compared the effects of recombinant brain natriuretic peptide on gastric mucosal microvascular haemoglobin oxygenation (reflectance spectrophotometry) and systemic variables with those of equi-hypotensive doses of two other vasodilators (nitroglycerine and dihydralazine). Chronically instrumented, healthy dogs were randomly allocated to receive on different days, one of the three drugs (nitroglycerine and dihydralazine doses titrated to reduce mean arterial pressure by similar to 20%). Brain natriuretic peptide significantly increased gastric mucosal microvascular haemoglobin oxygenation selectively, i.e. without concomitant haemodynamic effects. In contrast, the other vasodilators either did not increase gastric mucosal microvascular haemoglobin oxygenation at all (nitroglycerine), or did so only with marked increases in other systemic haemodynamic variables (dihydralazine). Our data suggest a potential role of recombinant brain natriuretic peptide selectively for increasing microvascular mucosal oxygenation. Studies are required to extend these findings to the clinical setting.

Original languageEnglish
Pages (from-to)501-507
Number of pages7
JournalAnaesthesia
Volume67
Issue number5
DOIs
Publication statusPublished - May-2012

Keywords

  • SEPTIC SHOCK
  • MESENTERIC VASOCONSTRICTION
  • SODIUM-NITROPRUSSIDE
  • VENTILATED DOGS
  • PULSE PRESSURE
  • HEART-FAILURE
  • TIDAL VOLUME
  • GAS-EXCHANGE
  • IN-VIVO
  • MICROCIRCULATION

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