The discovAIR project: a roadmap towards the Human Lung Cell Atlas

Malte D Luecken, Laure-Emmanuelle Zaragozi, Elo Madissoon, Lisa Sikkema, Alexandra B Firsova, Elena De Domenico, Louis Kümmerle, Adem Saglam, Marijn Berg, Aurore C A Gay, Janine Schniering, Christoph H Mayr, Xesús M Abalo, Ludvig Larsson, Alexandros Sountoulidis, Sarah Teichmann, Karen van Eunen, Gerard H Koppelman, Kourosh Saeb-Parsy, Sylvie LeroyPippa Powell, Ugis Sarkans, Wim Timens, Joakim Lundeberg, Maarten van den Berge, Mats Nilsson, Peter Horváth, Jessica Denning, Irene Papatheodorou, Joachim Schultze, Herbert B Schiller, Pascal Barbry, Ilya Petoukhov, Alexander V Misharin, Ian Adcock, Michael von Papen, Fabian J Theis, Christos Samakovlis, Kerstin B Meyer, Martijn C Nawijn

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

The Human Cell Atlas (HCA) consortium aims to establish an atlas of all organs in the healthy human body at single-cell resolution to increase our understanding of basic biological processes that govern development, physiology and anatomy, and to accelerate diagnosis and treatment of disease. The lung biological network of the HCA aims to generate the Human Lung Cell Atlas as a reference for the cellular repertoire, molecular cell states and phenotypes, and the cell-cell interactions that characterise normal lung homeostasis in healthy lung tissue. Such a reference atlas of the healthy human lung will facilitate mapping the changes in the cellular landscape in disease. The discovAIR project is one of six pilot actions for the HCA funded by the European Commission in the context of the H2020 framework program. DiscovAIR aims to establish the first draft of an integrated Human Lung Cell Atlas, combining single-cell transcriptional and epigenetic profiling with spatially resolving techniques on matched tissue samples, as well as including a number of chronic and infectious diseases of the lung. The integrated Lung Cell Atlas will be available as a resource for the wider respiratory community, including basic and translational scientists, clinical medicine, and the private sector, as well as for patients with lung disease and the interested lay public. We anticipate that the Lung Cell Atlas will be the founding stone for a more detailed understanding of the pathogenesis of lung diseases, guiding the design of novel diagnostics and preventive or curative interventions.

Original languageEnglish
JournalEuropean Respiratory Journal
DOIs
Publication statusE-pub ahead of print - 27-Jan-2022

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