The Distribution of Congenital Anomalies Within the VACTERL Association Among Tumor Necrosis Factor Antagonist-exposed Pregnancies Is Similar to the General Population

Hubertina J. M. J. Crijns, Janneke Jentink, Ester Garne, Christine C. Gispen-de Wied, Sabine M. J. M. Straus, Lolkje T. W. de Jong-van den Berg*, EUROCAT Working Grp, Marian Bakker

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Objective. To compare the distribution of congenital anomalies within the VACTERL association (vertebral defects, anal atresia, cardiac, tracheoesophageal, renal, and limb abnormalities) between patients exposed to tumor necrosis factor-alpha (TNF-alpha) antagonist and the general population.

Methods. Analysis for comparison of proportional differences to a previous publication between anomaly subgroups, according to subgroup definitions of the European Surveillance of Congenital Anomalies (EUROCAT), a population-based database.

Results. Most EUROCAT subgroups belonging to the VACTERL association contained only one or 2 records of TNF-a antagonist exposure, so comparison of proportions was imprecise. Only the category "limb abnormalities" showed a significantly higher proportion in the general population.

Conclusion. The high number of congenital anomalies belonging to the VACTERL association from a report of pregnancies exposed to TNF-alpha antagonists could not be confirmed using a population-based congenital anomaly database. (First Release July 1 2011; J Rheumatol 2011;38:1871-4; doi:10.3899/jrheum.101316)

Original languageEnglish
Pages (from-to)1871-1874
Number of pages5
JournalJournal of Rheumatology
Volume38
Issue number9
DOIs
Publication statusPublished - Sep-2011

Keywords

  • VACTERL ASSOCIATION
  • EUROCAT
  • TUMOR NECROSIS FACTOR ANTAGONISTS
  • BIRTH DEFECT
  • SAFETY
  • VATER ASSOCIATION
  • SPECTRUM
  • DEFECTS

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