Objective. To compare the distribution of congenital anomalies within the VACTERL association (vertebral defects, anal atresia, cardiac, tracheoesophageal, renal, and limb abnormalities) between patients exposed to tumor necrosis factor-alpha (TNF-alpha) antagonist and the general population.
Methods. Analysis for comparison of proportional differences to a previous publication between anomaly subgroups, according to subgroup definitions of the European Surveillance of Congenital Anomalies (EUROCAT), a population-based database.
Results. Most EUROCAT subgroups belonging to the VACTERL association contained only one or 2 records of TNF-a antagonist exposure, so comparison of proportions was imprecise. Only the category "limb abnormalities" showed a significantly higher proportion in the general population.
Conclusion. The high number of congenital anomalies belonging to the VACTERL association from a report of pregnancies exposed to TNF-alpha antagonists could not be confirmed using a population-based congenital anomaly database. (First Release July 1 2011; J Rheumatol 2011;38:1871-4; doi:10.3899/jrheum.101316)
- VACTERL ASSOCIATION
- TUMOR NECROSIS FACTOR ANTAGONISTS
- BIRTH DEFECT
- VATER ASSOCIATION