The Distribution of Congenital Anomalies Within the VACTERL Association Among Tumor Necrosis Factor Antagonist-exposed Pregnancies Is Similar to the General Population

Hubertina J. M. J. Crijns; Janneke Jentink; Ester Garne; Christine C. Gispen-de Wied; Sabine M. J. M. Straus; Lolkje T. W. de Jong-van den Berg; EUROCAT Working Grp; Marian Bakker

doi:10.3899/jrheum.101316

The Distribution of Congenital Anomalies Within the VACTERL Association Among Tumor Necrosis Factor Antagonist-exposed Pregnancies Is Similar to the General Population

Hubertina J. M. J. Crijns, Janneke Jentink, Ester Garne, Christine C. Gispen-de Wied, Sabine M. J. M. Straus, Lolkje T. W. de Jong-van den Berg^*, EUROCAT Working Grp, Marian Bakker

^*Corresponding author for this work

Reproductive Origins of Adult Health and Disease (ROAHD)

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Abstract

Objective. To compare the distribution of congenital anomalies within the VACTERL association (vertebral defects, anal atresia, cardiac, tracheoesophageal, renal, and limb abnormalities) between patients exposed to tumor necrosis factor-alpha (TNF-alpha) antagonist and the general population.

Methods. Analysis for comparison of proportional differences to a previous publication between anomaly subgroups, according to subgroup definitions of the European Surveillance of Congenital Anomalies (EUROCAT), a population-based database.

Results. Most EUROCAT subgroups belonging to the VACTERL association contained only one or 2 records of TNF-a antagonist exposure, so comparison of proportions was imprecise. Only the category "limb abnormalities" showed a significantly higher proportion in the general population.

Conclusion. The high number of congenital anomalies belonging to the VACTERL association from a report of pregnancies exposed to TNF-alpha antagonists could not be confirmed using a population-based congenital anomaly database. (First Release July 1 2011; J Rheumatol 2011;38:1871-4; doi:10.3899/jrheum.101316)

Original language	English
Pages (from-to)	1871-1874
Number of pages	5
Journal	Journal of Rheumatology
Volume	38
Issue number	9
DOIs	https://doi.org/10.3899/jrheum.101316
Publication status	Published - Sep-2011

Keywords

VACTERL ASSOCIATION
EUROCAT
TUMOR NECROSIS FACTOR ANTAGONISTS
BIRTH DEFECT
SAFETY
VATER ASSOCIATION
SPECTRUM
DEFECTS

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EUROCAT Northern Netherlands
van Kammen-Bergman, J. (Creator), de Walle, H. (Creator), Bakker, M. (Creator), Lutke, R. (Creator), Siemensma-Mühlenberg, N. (Creator), Siemensma-Mühlenberg, N. (Creator), Zetstra-van der Woude, P. (Creator) & Doornbos, F. (Creator), University of Groningen, 1981
https://www.umcg.nl/NL/Zorg/ouders/Deelname_wetenschappelijk_onderzoek/OnderzoekNaarAangeborenAandoeningen/Paginas/default.aspx and one more link, https://www.umcg.nl/SiteCollectionDocuments/Zorg/Ouders/Eurocat/Registry_description_NNL_final_version_jan2018.pdf (show fewer)
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Crijns, H. J. M. J., Jentink, J., Garne, E., Gispen-de Wied, C. C., Straus, S. M. J. M., de Jong-van den Berg, L. T. W., EUROCAT Working Grp, & Bakker, M. (2011). The Distribution of Congenital Anomalies Within the VACTERL Association Among Tumor Necrosis Factor Antagonist-exposed Pregnancies Is Similar to the General Population. Journal of Rheumatology, 38(9), 1871-1874. https://doi.org/10.3899/jrheum.101316

@article{a423a94cda5b4313848f43dd68fb931a,

title = "The Distribution of Congenital Anomalies Within the VACTERL Association Among Tumor Necrosis Factor Antagonist-exposed Pregnancies Is Similar to the General Population",

abstract = "Objective. To compare the distribution of congenital anomalies within the VACTERL association (vertebral defects, anal atresia, cardiac, tracheoesophageal, renal, and limb abnormalities) between patients exposed to tumor necrosis factor-alpha (TNF-alpha) antagonist and the general population.Methods. Analysis for comparison of proportional differences to a previous publication between anomaly subgroups, according to subgroup definitions of the European Surveillance of Congenital Anomalies (EUROCAT), a population-based database.Results. Most EUROCAT subgroups belonging to the VACTERL association contained only one or 2 records of TNF-a antagonist exposure, so comparison of proportions was imprecise. Only the category {"}limb abnormalities{"} showed a significantly higher proportion in the general population.Conclusion. The high number of congenital anomalies belonging to the VACTERL association from a report of pregnancies exposed to TNF-alpha antagonists could not be confirmed using a population-based congenital anomaly database. (First Release July 1 2011; J Rheumatol 2011;38:1871-4; doi:10.3899/jrheum.101316)",

keywords = "VACTERL ASSOCIATION, EUROCAT, TUMOR NECROSIS FACTOR ANTAGONISTS, BIRTH DEFECT, SAFETY, VATER ASSOCIATION, SPECTRUM, DEFECTS",

author = "Crijns, {Hubertina J. M. J.} and Janneke Jentink and Ester Garne and {Gispen-de Wied}, {Christine C.} and Straus, {Sabine M. J. M.} and {de Jong-van den Berg}, {Lolkje T. W.} and {EUROCAT Working Grp} and Marian Bakker",

year = "2011",

month = sep,

doi = "10.3899/jrheum.101316",

language = "English",

volume = "38",

pages = "1871--1874",

journal = "The Journal of Rheumatology",

issn = "0315-162X",

publisher = "J RHEUMATOL PUBL CO",

number = "9",

}

Crijns, HJMJ, Jentink, J, Garne, E, Gispen-de Wied, CC, Straus, SMJM, de Jong-van den Berg, LTW, EUROCAT Working Grp & Bakker, M 2011, 'The Distribution of Congenital Anomalies Within the VACTERL Association Among Tumor Necrosis Factor Antagonist-exposed Pregnancies Is Similar to the General Population', Journal of Rheumatology, vol. 38, no. 9, pp. 1871-1874. https://doi.org/10.3899/jrheum.101316

The Distribution of Congenital Anomalies Within the VACTERL Association Among Tumor Necrosis Factor Antagonist-exposed Pregnancies Is Similar to the General Population. / Crijns, Hubertina J. M. J.; Jentink, Janneke; Garne, Ester et al.

In: Journal of Rheumatology, Vol. 38, No. 9, 09.2011, p. 1871-1874.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The Distribution of Congenital Anomalies Within the VACTERL Association Among Tumor Necrosis Factor Antagonist-exposed Pregnancies Is Similar to the General Population

AU - Crijns, Hubertina J. M. J.

AU - Jentink, Janneke

AU - Garne, Ester

AU - Gispen-de Wied, Christine C.

AU - Straus, Sabine M. J. M.

AU - de Jong-van den Berg, Lolkje T. W.

AU - EUROCAT Working Grp

AU - Bakker, Marian

PY - 2011/9

Y1 - 2011/9

N2 - Objective. To compare the distribution of congenital anomalies within the VACTERL association (vertebral defects, anal atresia, cardiac, tracheoesophageal, renal, and limb abnormalities) between patients exposed to tumor necrosis factor-alpha (TNF-alpha) antagonist and the general population.Methods. Analysis for comparison of proportional differences to a previous publication between anomaly subgroups, according to subgroup definitions of the European Surveillance of Congenital Anomalies (EUROCAT), a population-based database.Results. Most EUROCAT subgroups belonging to the VACTERL association contained only one or 2 records of TNF-a antagonist exposure, so comparison of proportions was imprecise. Only the category "limb abnormalities" showed a significantly higher proportion in the general population.Conclusion. The high number of congenital anomalies belonging to the VACTERL association from a report of pregnancies exposed to TNF-alpha antagonists could not be confirmed using a population-based congenital anomaly database. (First Release July 1 2011; J Rheumatol 2011;38:1871-4; doi:10.3899/jrheum.101316)

AB - Objective. To compare the distribution of congenital anomalies within the VACTERL association (vertebral defects, anal atresia, cardiac, tracheoesophageal, renal, and limb abnormalities) between patients exposed to tumor necrosis factor-alpha (TNF-alpha) antagonist and the general population.Methods. Analysis for comparison of proportional differences to a previous publication between anomaly subgroups, according to subgroup definitions of the European Surveillance of Congenital Anomalies (EUROCAT), a population-based database.Results. Most EUROCAT subgroups belonging to the VACTERL association contained only one or 2 records of TNF-a antagonist exposure, so comparison of proportions was imprecise. Only the category "limb abnormalities" showed a significantly higher proportion in the general population.Conclusion. The high number of congenital anomalies belonging to the VACTERL association from a report of pregnancies exposed to TNF-alpha antagonists could not be confirmed using a population-based congenital anomaly database. (First Release July 1 2011; J Rheumatol 2011;38:1871-4; doi:10.3899/jrheum.101316)

KW - VACTERL ASSOCIATION

KW - EUROCAT

KW - TUMOR NECROSIS FACTOR ANTAGONISTS

KW - BIRTH DEFECT

KW - SAFETY

KW - VATER ASSOCIATION

KW - SPECTRUM

KW - DEFECTS

U2 - 10.3899/jrheum.101316

DO - 10.3899/jrheum.101316

M3 - Article

VL - 38

SP - 1871

EP - 1874

JO - The Journal of Rheumatology

JF - The Journal of Rheumatology

SN - 0315-162X

IS - 9

ER -

The Distribution of Congenital Anomalies Within the VACTERL Association Among Tumor Necrosis Factor Antagonist-exposed Pregnancies Is Similar to the General Population

Abstract

Keywords

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EUROCAT Northern Netherlands

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