TY - JOUR
T1 - The Dutch Incidence of Infantile Hypertrophic Pyloric Stenosis and the Influence of Seasons
AU - van den Bunder, Fenne A I M
AU - Allema, Jan Hein
AU - Benninga, Marc A
AU - de Blaauw, Ivo
AU - van de Brug, Tim
AU - den Dulk, Marcel
AU - Hulscher, Jan B F
AU - Keyzer-Dekker, Claudia M G
AU - Witvliet, Marieke J
AU - van Heurn, Ernest L W
AU - Derikx, Joep P M
N1 - Thieme. All rights reserved.
PY - 2021
Y1 - 2021
N2 - INTRODUCTION: Studies report contradicting results on the incidence of infantile hypertrophic pyloric stenosis (IHPS) and its association with seasons. We aim to assess the IHPS incidence in the Netherlands and to determine whether seasonal variation is present in a nationwide cohort.MATERIALS AND METHODS: All infants with IHPS hospitalized in the Netherlands between 2007 and 2017 were included in this retrospective cohort study. Incidence rates per 1,000 livebirths (LB) were calculated using total number of LB during the matched month, season, or year, respectively. Seasonal variation based on month of birth and month of surgery was analyzed using linear mixed model and one-way ANOVA, respectively.RESULTS: A total of 2,479 infants were included, of which the majority was male (75.9%). Median (interquartile range) age at surgery was 34 (18) days. The average IHPS incidence rate was 1.28 per 1,000 LB (variation: 1.09-1.47 per 1,000 LB). We did not find a conclusive trend over time in IHPS incidence. Differences in incidence between season of birth and season of surgery were not significant (p = 0.677 and p = 0.206, respectively).CONCLUSION: We found an average IHPS incidence of 1.28 per 1,000 LB in the Netherlands. Our results showed no changing trend in incidence and no seasonal variation.
AB - INTRODUCTION: Studies report contradicting results on the incidence of infantile hypertrophic pyloric stenosis (IHPS) and its association with seasons. We aim to assess the IHPS incidence in the Netherlands and to determine whether seasonal variation is present in a nationwide cohort.MATERIALS AND METHODS: All infants with IHPS hospitalized in the Netherlands between 2007 and 2017 were included in this retrospective cohort study. Incidence rates per 1,000 livebirths (LB) were calculated using total number of LB during the matched month, season, or year, respectively. Seasonal variation based on month of birth and month of surgery was analyzed using linear mixed model and one-way ANOVA, respectively.RESULTS: A total of 2,479 infants were included, of which the majority was male (75.9%). Median (interquartile range) age at surgery was 34 (18) days. The average IHPS incidence rate was 1.28 per 1,000 LB (variation: 1.09-1.47 per 1,000 LB). We did not find a conclusive trend over time in IHPS incidence. Differences in incidence between season of birth and season of surgery were not significant (p = 0.677 and p = 0.206, respectively).CONCLUSION: We found an average IHPS incidence of 1.28 per 1,000 LB in the Netherlands. Our results showed no changing trend in incidence and no seasonal variation.
U2 - 10.1055/s-0040-1721055
DO - 10.1055/s-0040-1721055
M3 - Article
C2 - 33171518
SN - 0939-7248
VL - 31
SP - 525
EP - 529
JO - European Journal of Pediatric Surgery
JF - European Journal of Pediatric Surgery
IS - 06
ER -