The Effect of Rate Control on Quality of Life in Patients With Permanent Atrial Fibrillation Data From the RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation II) Study

H.F. Groenveld; H.J.G.M. Crijns; M.P. Van den Berg; E. van Sonderen; A.M. Alings; J.G.P. Tijssen; H.L. Hillege; Y.S. Tuininga; D.J. van Veldhuisen; A.V. Ranchor; I.C. Van Gelder

doi:10.1016/j.jacc.2011.06.055

The Effect of Rate Control on Quality of Life in Patients With Permanent Atrial Fibrillation Data From the RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation II) Study

H.F. Groenveld, H.J.G.M. Crijns, M.P. Van den Berg, E. van Sonderen, A.M. Alings, J.G.P. Tijssen, H.L. Hillege, Y.S. Tuininga, D.J. van Veldhuisen, A.V. Ranchor, I.C. Van Gelder

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Abstract

Objectives The aim of this study was to investigate the influence of rate control on quality of life (QOL).

Background The RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation II) trial showed that lenient rate control is not inferior to strict rate control in terms of cardiovascular morbidity and mortality. The influence of stringency of rate control on QOL is unknown.

Methods In RACE II, a total of 614 patients with permanent atrial fibrillation (AF) were randomized to lenient (resting heart rate [HR]

Results Median follow-up was 3 years. Mean age was 68 +/- 8 years, and 66% were males. At the end of follow-up, all SF-36 subscales were comparable between both groups. The AF severity scale was similar at baseline and end of study. At baseline and at end of study there were no differences in the MFI-20 subscales between the 2 groups. Symptoms at baseline, younger age, and less severe underlying disease, rather than assigned therapy or heart rate, were associated with QOL improvements. Female sex and cardiovascular endpoints during the study were associated with worsening of QOL.

Conclusions Stringency of heart rate control does not influence QOL. Instead, symptoms, sex, age, and severity of the underlying disease influence QOL. (Rate Control Efficacy in Permanent Atrial Fibrillation; NCT00392613) (J Am Coll Cardiol 2011;58:1795-803) (C) 2011 by the American College of Cardiology Foundation

Original language	English
Pages (from-to)	1795-1803
Number of pages	9
Journal	Journal of the American College of Cardiology
Volume	58
Issue number	17
DOIs	https://doi.org/10.1016/j.jacc.2011.06.055
Publication status	Published - 18-Oct-2011

Keywords

atrial fibrillation
quality of life
rate control
STRICT RATE CONTROL
ELECTRICAL CARDIOVERSION RACE
GENDER-RELATED DIFFERENCES
RHYTHM MANAGEMENT AFFIRM
SF-36 HEALTH SURVEY
EURO HEART SURVEY
TASK-FORCE
FATIGUE
LENIENT
IMPAIRMENT

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Groenveld, H. F., Crijns, H. J. G. M., Van den Berg, M. P., van Sonderen, E., Alings, A. M., Tijssen, J. G. P., Hillege, H. L., Tuininga, Y. S., van Veldhuisen, D. J., Ranchor, A. V., & Van Gelder, I. C. (2011). The Effect of Rate Control on Quality of Life in Patients With Permanent Atrial Fibrillation Data From the RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation II) Study. Journal of the American College of Cardiology, 58(17), 1795-1803. https://doi.org/10.1016/j.jacc.2011.06.055

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title = "The Effect of Rate Control on Quality of Life in Patients With Permanent Atrial Fibrillation Data From the RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation II) Study",

abstract = "Objectives The aim of this study was to investigate the influence of rate control on quality of life (QOL).Background The RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation II) trial showed that lenient rate control is not inferior to strict rate control in terms of cardiovascular morbidity and mortality. The influence of stringency of rate control on QOL is unknown.Methods In RACE II, a total of 614 patients with permanent atrial fibrillation (AF) were randomized to lenient (resting heart rate [HR]Results Median follow-up was 3 years. Mean age was 68 +/- 8 years, and 66% were males. At the end of follow-up, all SF-36 subscales were comparable between both groups. The AF severity scale was similar at baseline and end of study. At baseline and at end of study there were no differences in the MFI-20 subscales between the 2 groups. Symptoms at baseline, younger age, and less severe underlying disease, rather than assigned therapy or heart rate, were associated with QOL improvements. Female sex and cardiovascular endpoints during the study were associated with worsening of QOL.Conclusions Stringency of heart rate control does not influence QOL. Instead, symptoms, sex, age, and severity of the underlying disease influence QOL. (Rate Control Efficacy in Permanent Atrial Fibrillation; NCT00392613) (J Am Coll Cardiol 2011;58:1795-803) (C) 2011 by the American College of Cardiology Foundation",

keywords = "atrial fibrillation, quality of life, rate control, STRICT RATE CONTROL, ELECTRICAL CARDIOVERSION RACE, GENDER-RELATED DIFFERENCES, RHYTHM MANAGEMENT AFFIRM, SF-36 HEALTH SURVEY, EURO HEART SURVEY, TASK-FORCE, FATIGUE, LENIENT, IMPAIRMENT",

author = "H.F. Groenveld and H.J.G.M. Crijns and {Van den Berg}, M.P. and {van Sonderen}, E. and A.M. Alings and J.G.P. Tijssen and H.L. Hillege and Y.S. Tuininga and {van Veldhuisen}, D.J. and A.V. Ranchor and {Van Gelder}, I.C.",

year = "2011",

month = oct,

day = "18",

doi = "10.1016/j.jacc.2011.06.055",

language = "English",

volume = "58",

pages = "1795--1803",

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issn = "1558-3597",

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Groenveld, HF, Crijns, HJGM, Van den Berg, MP , van Sonderen, E, Alings, AM, Tijssen, JGP, Hillege, HL, Tuininga, YS, van Veldhuisen, DJ , Ranchor, AV & Van Gelder, IC 2011, 'The Effect of Rate Control on Quality of Life in Patients With Permanent Atrial Fibrillation Data From the RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation II) Study', Journal of the American College of Cardiology, vol. 58, no. 17, pp. 1795-1803. https://doi.org/10.1016/j.jacc.2011.06.055

The Effect of Rate Control on Quality of Life in Patients With Permanent Atrial Fibrillation Data From the RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation II) Study. / Groenveld, H.F.; Crijns, H.J.G.M.; Van den Berg, M.P. et al.
In: Journal of the American College of Cardiology, Vol. 58, No. 17, 18.10.2011, p. 1795-1803.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The Effect of Rate Control on Quality of Life in Patients With Permanent Atrial Fibrillation Data From the RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation II) Study

AU - Groenveld, H.F.

AU - Crijns, H.J.G.M.

AU - Van den Berg, M.P.

AU - van Sonderen, E.

AU - Alings, A.M.

AU - Tijssen, J.G.P.

AU - Hillege, H.L.

AU - Tuininga, Y.S.

AU - van Veldhuisen, D.J.

AU - Ranchor, A.V.

AU - Van Gelder, I.C.

PY - 2011/10/18

Y1 - 2011/10/18

N2 - Objectives The aim of this study was to investigate the influence of rate control on quality of life (QOL).Background The RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation II) trial showed that lenient rate control is not inferior to strict rate control in terms of cardiovascular morbidity and mortality. The influence of stringency of rate control on QOL is unknown.Methods In RACE II, a total of 614 patients with permanent atrial fibrillation (AF) were randomized to lenient (resting heart rate [HR]Results Median follow-up was 3 years. Mean age was 68 +/- 8 years, and 66% were males. At the end of follow-up, all SF-36 subscales were comparable between both groups. The AF severity scale was similar at baseline and end of study. At baseline and at end of study there were no differences in the MFI-20 subscales between the 2 groups. Symptoms at baseline, younger age, and less severe underlying disease, rather than assigned therapy or heart rate, were associated with QOL improvements. Female sex and cardiovascular endpoints during the study were associated with worsening of QOL.Conclusions Stringency of heart rate control does not influence QOL. Instead, symptoms, sex, age, and severity of the underlying disease influence QOL. (Rate Control Efficacy in Permanent Atrial Fibrillation; NCT00392613) (J Am Coll Cardiol 2011;58:1795-803) (C) 2011 by the American College of Cardiology Foundation

AB - Objectives The aim of this study was to investigate the influence of rate control on quality of life (QOL).Background The RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation II) trial showed that lenient rate control is not inferior to strict rate control in terms of cardiovascular morbidity and mortality. The influence of stringency of rate control on QOL is unknown.Methods In RACE II, a total of 614 patients with permanent atrial fibrillation (AF) were randomized to lenient (resting heart rate [HR]Results Median follow-up was 3 years. Mean age was 68 +/- 8 years, and 66% were males. At the end of follow-up, all SF-36 subscales were comparable between both groups. The AF severity scale was similar at baseline and end of study. At baseline and at end of study there were no differences in the MFI-20 subscales between the 2 groups. Symptoms at baseline, younger age, and less severe underlying disease, rather than assigned therapy or heart rate, were associated with QOL improvements. Female sex and cardiovascular endpoints during the study were associated with worsening of QOL.Conclusions Stringency of heart rate control does not influence QOL. Instead, symptoms, sex, age, and severity of the underlying disease influence QOL. (Rate Control Efficacy in Permanent Atrial Fibrillation; NCT00392613) (J Am Coll Cardiol 2011;58:1795-803) (C) 2011 by the American College of Cardiology Foundation

KW - atrial fibrillation

KW - quality of life

KW - rate control

KW - STRICT RATE CONTROL

KW - ELECTRICAL CARDIOVERSION RACE

KW - GENDER-RELATED DIFFERENCES

KW - RHYTHM MANAGEMENT AFFIRM

KW - SF-36 HEALTH SURVEY

KW - EURO HEART SURVEY

KW - TASK-FORCE

KW - FATIGUE

KW - LENIENT

KW - IMPAIRMENT

U2 - 10.1016/j.jacc.2011.06.055

DO - 10.1016/j.jacc.2011.06.055

M3 - Article

SN - 1558-3597

VL - 58

SP - 1795

EP - 1803

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

IS - 17

ER -

Groenveld HF, Crijns HJGM, Van den Berg MP , van Sonderen E, Alings AM, Tijssen JGP et al. The Effect of Rate Control on Quality of Life in Patients With Permanent Atrial Fibrillation Data From the RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation II) Study. Journal of the American College of Cardiology. 2011 Oct 18;58(17):1795-1803. doi: 10.1016/j.jacc.2011.06.055

The Effect of Rate Control on Quality of Life in Patients With Permanent Atrial Fibrillation Data From the RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation II) Study

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Keywords

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