The effect of treatment with bisoprolol-first versus enalapril-first on cardiac structure and function in heart failure

Louis L. M. Van de Ven, Dirk J. van Veldhuisen, Michael Goulder, Zsolt Zilahi, Wilfried R. Meyer, Ronnie Willenheimer*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Abstract

Background: In CIBIS III, initiating chronic heart failure (CHF) treatment with bisoprolol (target dose 10 mg q.d.) followed by combination therapy with enalapril (target dose 10 mg b.i.d.), compared to the opposite order, showed similar effects on survival and hospitalization. By echocardiography, we evaluated the effects of these treatment strategies on cardiac structure and function. Methods: In a single-centre substudy, we compared the impact on left ventricular (LV) dimensions and ejection fraction (EF) of treatment with bisoprolol-first (n = 21) and enalapril-first (n = 19) in 40 beta-blocker and angiotensin-converting-enzyme-inhibitor naive patients, with stable, mild or moderate CHF (NYHA II-III) and LVEF

Original languageEnglish
Pages (from-to)59-63
Number of pages5
JournalInternational Journal of Cardiology
Volume144
Issue number1
DOIs
Publication statusPublished - 24-Sept-2010

Keywords

  • Heart failure
  • Drugs
  • Adrenergic beta-antagonists
  • Angiotensin-converting enzyme inhibitors
  • Cardiac remodelling
  • LEFT-VENTRICULAR DYSFUNCTION
  • INSUFFICIENCY BISOPROLOL
  • CIBIS-III
  • CARVEDILOL
  • TRIAL
  • METOPROLOL
  • INITIATION
  • INHIBITOR
  • FRACTION
  • THERAPY

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