THE EFFECTS OF DIFFERENT STEAM-STERILIZATION PROGRAMS ON MATERIAL PROPERTIES OF POLY(L-LACTIDE)

FR ROZEMA*, RRM BOS, G BOERING, JAAM VANASTEN, AJ NIJENHUIS, AJ PENNINGS

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

36 Citations (Scopus)

Abstract

As-polymerized poly(L-lactide) test rods were sterilized by seven different specially designed computer-operated autoclaving programs. As a control, common hospital sterilization was performed. In all cases, the molecular weight decreased after sterilization. A short time high-temperature sterilization lead to less molecular weight decrease than a low sterilization temperature cycle with a longer sterilization time. Regular hospital sterilization significantly reduced the elongation at break and also resulted in a decrease of 35% in tensile strength. The program causing minimal damage to the material properties was studied in detail. This program, with a sterilization period of 60 s and 129-degrees-C, was effective for PLLA sterilization and also looks very promising for sterilization of other thermo- and moisture-labile polymers.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalJournal of applied biomaterials
Volume2
Issue number1
Publication statusPublished - 1991

Keywords

  • ETHYLENE-OXIDE
  • RESORBABLE MATERIALS
  • POLY(EPSILON-CAPROLACTONE)
  • DEGRADATION
  • COPOLYMERS
  • POLYESTERS
  • FIXATION
  • POLYMERS
  • PLATES
  • SCREWS

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