As-polymerized poly(L-lactide) test rods were sterilized by seven different specially designed computer-operated autoclaving programs. As a control, common hospital sterilization was performed. In all cases, the molecular weight decreased after sterilization. A short time high-temperature sterilization lead to less molecular weight decrease than a low sterilization temperature cycle with a longer sterilization time. Regular hospital sterilization significantly reduced the elongation at break and also resulted in a decrease of 35% in tensile strength. The program causing minimal damage to the material properties was studied in detail. This program, with a sterilization period of 60 s and 129-degrees-C, was effective for PLLA sterilization and also looks very promising for sterilization of other thermo- and moisture-labile polymers.
|Number of pages||6|
|Journal||Journal of applied biomaterials|
|Publication status||Published - 1991|
- RESORBABLE MATERIALS