The effects on plasma, red cell and platelet fatty acids of taking 12 g/day of ethyl-eicosapentaenoate for 16 months: dihomogammalinolenic, arachidonic and docosahexaenoic acids and relevance to Inuit metabolism

David Horrobin; M Rebecca Fokkema; Frits A J Muskiet

doi:10.1016/S0952-3278(03)00007-3

The effects on plasma, red cell and platelet fatty acids of taking 12 g/day of ethyl-eicosapentaenoate for 16 months: dihomogammalinolenic, arachidonic and docosahexaenoic acids and relevance to Inuit metabolism

David Horrobin, M Rebecca Fokkema, Frits A J Muskiet

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

Abstract

A patient with mantle cell lymphoma took 12g/day of ethyl-eicosapentaenoate for 16 months. Compared to reference values, eicosapentaenoic and docosapentaenoic acids were elevated in plasma, red cells and platelets but docosahexaenoic acid levels were in the normal range. Arachidonic acid levels were moderately reduced but dihomogammalinolenic acid levels remained in the normal range. In spite of a long chain n-3 fatty acid intake higher than in most Inuit populations, arachidonic acid levels remained considerably higher in this patient than in the Inuit. The implications for understanding of fatty acid metabolism in humans are discussed.

Original language	English
Pages (from-to)	301-304
Number of pages	4
Journal	Prostaglandins Leukotrienes and Essential Fatty Acids
Volume	68
Issue number	5
DOIs	https://doi.org/10.1016/S0952-3278(03)00007-3
Publication status	Published - May-2003

Keywords

GAMMA-LINOLENIC ACID
ESKIMOS
PROSTAGLANDIN-E1

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Horrobin, D., Fokkema, M. R., & Muskiet, F. A. J. (2003). The effects on plasma, red cell and platelet fatty acids of taking 12 g/day of ethyl-eicosapentaenoate for 16 months: dihomogammalinolenic, arachidonic and docosahexaenoic acids and relevance to Inuit metabolism. Prostaglandins Leukotrienes and Essential Fatty Acids, 68(5), 301-304. https://doi.org/10.1016/S0952-3278(03)00007-3

Horrobin, David ; Fokkema, M Rebecca ; Muskiet, Frits A J. / The effects on plasma, red cell and platelet fatty acids of taking 12 g/day of ethyl-eicosapentaenoate for 16 months : dihomogammalinolenic, arachidonic and docosahexaenoic acids and relevance to Inuit metabolism. In: Prostaglandins Leukotrienes and Essential Fatty Acids. 2003 ; Vol. 68, No. 5. pp. 301-304.

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title = "The effects on plasma, red cell and platelet fatty acids of taking 12 g/day of ethyl-eicosapentaenoate for 16 months: dihomogammalinolenic, arachidonic and docosahexaenoic acids and relevance to Inuit metabolism",

abstract = "A patient with mantle cell lymphoma took 12g/day of ethyl-eicosapentaenoate for 16 months. Compared to reference values, eicosapentaenoic and docosapentaenoic acids were elevated in plasma, red cells and platelets but docosahexaenoic acid levels were in the normal range. Arachidonic acid levels were moderately reduced but dihomogammalinolenic acid levels remained in the normal range. In spite of a long chain n-3 fatty acid intake higher than in most Inuit populations, arachidonic acid levels remained considerably higher in this patient than in the Inuit. The implications for understanding of fatty acid metabolism in humans are discussed.",

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Horrobin, D, Fokkema, MR & Muskiet, FAJ 2003, 'The effects on plasma, red cell and platelet fatty acids of taking 12 g/day of ethyl-eicosapentaenoate for 16 months: dihomogammalinolenic, arachidonic and docosahexaenoic acids and relevance to Inuit metabolism', Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 68, no. 5, pp. 301-304. https://doi.org/10.1016/S0952-3278(03)00007-3

The effects on plasma, red cell and platelet fatty acids of taking 12 g/day of ethyl-eicosapentaenoate for 16 months: dihomogammalinolenic, arachidonic and docosahexaenoic acids and relevance to Inuit metabolism. / Horrobin, David; Fokkema, M Rebecca; Muskiet, Frits A J.
In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 68, No. 5, 05.2003, p. 301-304.

Research output: Contribution to journal › Article › Academic › peer-review

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