The epidermal growth factor receptor pathway in chronic kidney diseases

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44 Citations (Scopus)

Abstract

The epidermal growth factor receptor (EGFR) pathway has a critical role in renal development, tissue repair and electrolyte handling. Numerous studies have reported an association between dysregulation of this pathway and the initiation and progression of various chronic kidney diseases such as diabetic nephropathy, chronic allograft nephropathy and polycystic kidney disease through the promotion of renal cell proliferation, fibrosis and inflammation. In the oncological setting, compounds that target the EGFR pathway are already in clinical use or have been evaluated in clinical trials; in the renal setting, therapeutic interventions targeting this pathway by decreasing ligand availability with disintegrin and metalloproteinase inhibitors or with ligand-neutralizing antibodies, or by inhibiting receptor activation with tyrosine kinase inhibitors or monoclonal antibodies are only just starting to be explored in animal models of chronic kidney disease and in patients with autosomal dominant polycystic kidney disease. In this Review we focus on the role of the EGFR signalling pathway in the kidney under physiological conditions and during the pathophysiology of chronic kidney diseases and explore the clinical potential of interventions in this pathway to treat chronic renal diseases.

Original languageEnglish
Pages (from-to)496-506
Number of pages11
JournalNature Reviews Nephrology
Volume12
Issue number8
DOIs
Publication statusPublished - Aug-2016

Keywords

  • ALPHA-CONVERTING-ENZYME
  • TYROSINE KINASE-ACTIVITY
  • IN-SITU HYBRIDIZATION
  • NORMAL HUMAN ADULT
  • EGF-RECEPTOR
  • DIABETIC-NEPHROPATHY
  • RENAL FIBROSIS
  • ANGIOTENSIN-II
  • MESSENGER-RNA
  • INSULIN-RESISTANCE

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