THE EVOLUTION OF IMMUNE MEMORY AND GERMINAL-CENTERS

MH NAHM*, FGM KROESE, JW HOFFMANN

*Corresponding author for this work

Research output: Contribution to journalEditorialAcademicpeer-review

29 Citations (Scopus)

Abstract

Antibody responses in homoiothermic and poikilothermic vertebrates are significantly different in their heterogeneity and affinity range, and in the speed of the secondary response following repeated antigenic stimulation. This article presents the hypothesis that the evolutionary development of unique lymphoid structures, the germinal centers, in combination with the development of a distinct B-cell lineage, is a determining feature of these differences.

Original languageEnglish
Pages (from-to)438-441
Number of pages4
JournalImmunology Today
Volume13
Issue number11
Publication statusPublished - Nov-1992

Keywords

  • CENTER B-CELLS
  • ANTIBODY-RESPONSE
  • ANTIGEN
  • COMPLEMENT
  • AFFINITY
  • SYSTEM
  • SPLEEN

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