The expression pattern of MUC1 (EMA) is related to tumour characteristics and clinical outcome of invasive ductal breast carcinoma

B. van der Vegt, J. L. Peterse, C. Patriarca, J. Hilkens, G. H. de Bock, J. Wesseling*, M.A.J. de Roos

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

47 Citations (Scopus)
268 Downloads (Pure)

Abstract

Aims: To clarify MUC1 patterns in invasive ductal breast carcinoma and to relate them to clinicopathological parameters, coexpression of other biological markers and prognosis.

Methods and results: Samples from 243 consecutive patients with primary ductal carcinoma were incorporated into tissue microarrays (TMAs). Slides were stained for MUC1, oestrogen receptor (ER), progesterone receptor (PR), Her2/neu, p53 and cyclin D1. Apical membrane MUC1 expression was associated with smaller tumours (P = 0.001), lower tumour grades (P <0.001), PR positivity (P = 0.003) and increased overall survival (OS; P = 0.030). Diffuse cytoplasmic MUC1 expression was associated with cyclin D1 positivity (P = 0.009) and increased relapse-free survival (RFS; P = 0.034). Negativity for MUC1 was associated with ER negativity (P = 0.004), PR negativity (P = 0.001) and cyclin D1 negativity (P = 0.009). In stepwise multivariate analysis MUC1 negativity was an independent predictor of both RFS [hazard ratio (HR) 3.5, 95% confidence interval (CI) 1.5, 8.5; P = 0.005] and OS (HR 14.7, 9 5% Cl 4.9, 44. 1; P <0.001).

Conclusions: The expression pattern of MUC1 in invasive ductal breast carcinoma is related to tumour characteristics and clinical outcome. In addition, negative MUC1 expression is an independent risk factor for poor RFS and OS, besides 'classical' prognostic indicators.

Original languageEnglish
Pages (from-to)322-335
Number of pages14
JournalHistopathology
Volume51
Issue number3
DOIs
Publication statusPublished - Sep-2007

Keywords

  • breast carcinoma
  • ductal
  • immunohistochemistry
  • MUC1
  • prognosis
  • tissue microarray
  • EPITHELIAL MUCIN
  • MONOCLONAL-ANTIBODY
  • PROGNOSTIC-SIGNIFICANCE
  • CYTOPLASMIC TAIL
  • EPISIALIN MUC1
  • MAMMARY-GLAND
  • CELL-ADHESION
  • CANCER
  • DIFFERENTIATION
  • GLYCOSYLATION

Cite this