The HDL anti-inflammatory function is impaired in myocardial infarction and may predict new cardiac events independent of HDL cholesterol

Robin P. F. Dullaart*, Wijtske Annema, Rene A. Tio, Uwe J. F. Tietge

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

25 Citations (Scopus)

Abstract

Background: Intrinsic functional properties of high density lipoproteins (HDL) are considered to be physiologically important for atheroprotection. We compared the HDL anti-inflammatory capacity between patients with acute myocardial infarction (MI) and patients with non-cardiac chest pain, and prospectively determined the association of new major adverse cardiovascular events (MACE) with this metric of HDL function.

Methods: A prospective study was carried out in 93 patients referred for acute chest pain (65 patients with acute MI). The HDL anti-inflammatory capacity was determined as the ability to suppress tumor necrosis factor-alpha-induced vascular cell adhesion molecule-1 mRNA expression in endothelial cells in vitro.

Results: Acute MI at admission was associated with impaired HDL anti-inflammatory capacity (p = 0.001), even after adjustment for HDL cholesterol and apolipoprotein A-I (p = 0.003). Twenty nine MACE were ascertained during a median follow-up of 1210 (910-1679) days. New MACE was associated with impaired HDL anti-inflammatory capacity (hazard ratio: 1.80 (1.17-2.77) per SD change, p = 0.007) in age, sex, HDL cholesterol and apolipoprotein-AI adjusted analysis.

Conclusions: The ability of HDL to attenuate endothelial inflammation is impaired in acute MI, and this metric of HDL function may serve as a predictor of new MACE, even independent of HDL cholesterol and apolipoprotein A-I. (C) 2014 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)34-38
Number of pages5
JournalClinica chimica acta
Volume433
DOIs
Publication statusPublished - 10-Jun-2014

Keywords

  • Acute coronary syndrome
  • Atypical chest pain
  • HDL anti-inflammatory function
  • STEMI
  • Non-STEMI
  • HIGH-DENSITY-LIPOPROTEIN
  • ACUTE CORONARY SYNDROME
  • THERAPEUTIC TARGET
  • CHEST-PAIN
  • EFFLUX
  • ATHEROSCLEROSIS
  • MORTALITY
  • CAPACITY
  • DISEASE
  • RISK

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