The hemostatic status of pediatric recipients of adult liver grafts suggests that plasma levels of hemostatic proteins are not regulated by the liver

Ton Lisman*, Marco Platto, Joost C. M. Meijers, Elizabeth B. Haagsma, Michele Colledan, Robert J. Porte

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Abstract

Plasma levels of coagulation factors differ profoundly between adults and children, but are remarkably stable throughout adulthood. It is unknown which factors determine plasma levels of coagulation factors in a given individual. We hypothesized that the liver, which synthesizes coagulation factors, also controls plasma levels. We measured a panel of coagulation factors in samples taken from either adults or young children who underwent a liver transplantation with adult donor livers. Samples were taken 1-3 months after transplantation, when the patients were clinically stable with adequate graft function. After liver transplantation, the hemostatic profile of the pediatric group was remarkably different from that of the adult group, and resembled the hemostatic profile of normal children. Thus, children transplanted with an adult liver graft maintain a pediatric hemostatic profile after transplantation despite receiving an adult liver graft. These findings suggest that plasma levels of hemostatic proteins are not controlled by the liver. (Blood. 2011; 117(6): 2070-2072)

Original languageEnglish
Pages (from-to)2070-2072
Number of pages3
JournalBlood
Volume117
Issue number6
DOIs
Publication statusPublished - 10-Feb-2011

Keywords

  • HUMAN COAGULATION SYSTEM
  • PHARMACOKINETICS
  • CHILDREN
  • INFANT

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