Abstract
The binding of [3H] corticosterone to hippocampal cytosol receptors of Brattleboro rats homozygous for diabetes insipidus (Ho-Di) and of normal Brattleboro rats (Ho-No) was investigated at 24 h after removal of the adrenals. The apparent maximal binding capacity of the Ho-Di hippocampal corticosterone receptor system was about 30% less than that of the Ho-No rats. Substitution of the vasopressin deficient rats with 1E pitressin tannate in oil partially restores the hippocampal corticosterone receptor level towards that of the control animals.
| Original language | English |
|---|---|
| Pages (from-to) | 187-92 |
| Number of pages | 6 |
| Journal | Neuroscience Letters |
| Volume | 16 |
| Issue number | 2 |
| Publication status | Published - Feb-1980 |
Keywords
- Adrenalectomy
- Animals
- Diabetes Insipidus
- Hippocampus
- Homozygote
- Male
- Rats
- Rats, Brattleboro
- Receptors, Glucocorticoid
- Receptors, Steroid
- Vasopressins