The History of Target-Controlled Infusion

Michel M. R. F. Struys; Tom De Smet; John (Iain) B. Glen; Hugo E. M. Vereecke; Anthony R. Absalom; Thomas W. Schnider

doi:10.1213/ANE.0000000000001008

The History of Target-Controlled Infusion

Michel M. R. F. Struys^*, Tom De Smet, John (Iain) B. Glen, Hugo E. M. Vereecke, Anthony R. Absalom, Thomas W. Schnider

^*Corresponding author for this work

Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE)

Research output: Contribution to journal › Review article › peer-review

103 Citations (Scopus)

995 Downloads (Pure)

Abstract

Target-controlled infusion (TCI) is a technique of infusing IV drugs to achieve a user-defined predicted (target) drug concentration in a specific body compartment or tissue of interest. In this review, we describe the pharmacokinetic principles of TCI, the development of TCI systems, and technical and regulatory issues addressed in prototype development. We also describe the launch of the current clinically available systems.

Original language	English
Pages (from-to)	56-69
Number of pages	14
Journal	Anesthesia and Analgesia
Volume	122
Issue number	1
DOIs	https://doi.org/10.1213/ANE.0000000000001008
Publication status	Published - Jan-2016

Keywords

COMPUTER-CONTROLLED INFUSION
3-COMPARTMENT PHARMACOKINETIC MODEL
TOTAL INTRAVENOUS ANESTHESIA
NITROUS-OXIDE ANESTHESIA
LOWER ABDOMINAL-SURGERY
DRIVEN DRUG-DELIVERY
PLASMA-CONCENTRATIONS
ASSISTED INFUSION
BISPECTRAL INDEX
GENERAL-ANESTHESIA

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title = "The History of Target-Controlled Infusion",

abstract = "Target-controlled infusion (TCI) is a technique of infusing IV drugs to achieve a user-defined predicted (target) drug concentration in a specific body compartment or tissue of interest. In this review, we describe the pharmacokinetic principles of TCI, the development of TCI systems, and technical and regulatory issues addressed in prototype development. We also describe the launch of the current clinically available systems.",

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author = "Struys, {Michel M. R. F.} and {De Smet}, Tom and Glen, {John (Iain) B.} and Vereecke, {Hugo E. M.} and Absalom, {Anthony R.} and Schnider, {Thomas W.}",

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AU - Struys, Michel M. R. F.

AU - De Smet, Tom

AU - Glen, John (Iain) B.

AU - Vereecke, Hugo E. M.

AU - Absalom, Anthony R.

AU - Schnider, Thomas W.

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KW - 3-COMPARTMENT PHARMACOKINETIC MODEL

KW - TOTAL INTRAVENOUS ANESTHESIA

KW - NITROUS-OXIDE ANESTHESIA

KW - LOWER ABDOMINAL-SURGERY

KW - DRIVEN DRUG-DELIVERY

KW - PLASMA-CONCENTRATIONS

KW - ASSISTED INFUSION

KW - BISPECTRAL INDEX

KW - GENERAL-ANESTHESIA

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M3 - Review article

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EP - 69

JO - Anesthesia and Analgesia

JF - Anesthesia and Analgesia

IS - 1

ER -

The History of Target-Controlled Infusion

Abstract

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