The IL-7R alpha Pathway Is Quantitatively and Functionally Altered in CD8 T Cells in Multiple Sclerosis

Karim L. Kreft; Evert Verbraak; Annet F. Wierenga-Wolf; Marjan van Meurs; Ben A. Oostra; Jon D. Laman; Rogier Q. Hintzen

doi:10.4049/jimmunol.1102559

The IL-7R alpha Pathway Is Quantitatively and Functionally Altered in CD8 T Cells in Multiple Sclerosis

Karim L. Kreft, Evert Verbraak, Annet F. Wierenga-Wolf, Marjan van Meurs, Ben A. Oostra, Jon D. Laman, Rogier Q. Hintzen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

26 Citations (Scopus)

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Abstract

The IL-7R alpha single nucleotide polymorphism rs6897932 is associated with an increased risk for multiple sclerosis (MS). IL-7Ra is a promising candidate to be involved in autoimmunity, because it regulates T cell homeostasis, proliferation, and antiapoptotic signaling. However, the exact underlying mechanisms in the pathogenesis of MS are poorly understood. We investigated whether CD4 and CD8 lymphocyte subsets differed in IL-7R alpha expression and functionality in 78 MS patients compared with 59 healthy controls (HC). A significantly higher frequency of IL-7R alpha(+) CD8 effector memory (CD8EM) was found in MS. Moreover, IL-7R alpha membrane expression was significantly increased in MS in naive and memory CD8 (all p

Original language	English
Pages (from-to)	1874-1883
Number of pages	10
Journal	Journal of Immunology
Volume	188
Issue number	4
DOIs	https://doi.org/10.4049/jimmunol.1102559
Publication status	Published - 15-Feb-2012
Externally published	Yes

Keywords

CENTRAL-NERVOUS-SYSTEM
INTERLEUKIN-7 RECEPTOR
RHEUMATOID-ARTHRITIS
LYMPHOCYTE SUBSETS
PERIPHERAL-BLOOD
EXPRESSION
RISK
MEMORY
LESIONS
INFLAMMATION

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The IL-7Rα Pathway Is Quantitatively and Functionally Altered in CD8 T Cells in Multiple SclerosisFinal publisher's version, 2.16 MBLicence: Taverne

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@article{0de683a823ec4894911ba9becd691235,

title = "The IL-7R alpha Pathway Is Quantitatively and Functionally Altered in CD8 T Cells in Multiple Sclerosis",

abstract = "The IL-7R alpha single nucleotide polymorphism rs6897932 is associated with an increased risk for multiple sclerosis (MS). IL-7Ra is a promising candidate to be involved in autoimmunity, because it regulates T cell homeostasis, proliferation, and antiapoptotic signaling. However, the exact underlying mechanisms in the pathogenesis of MS are poorly understood. We investigated whether CD4 and CD8 lymphocyte subsets differed in IL-7R alpha expression and functionality in 78 MS patients compared with 59 healthy controls (HC). A significantly higher frequency of IL-7R alpha(+) CD8 effector memory (CD8EM) was found in MS. Moreover, IL-7R alpha membrane expression was significantly increased in MS in naive and memory CD8 (all p",

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author = "Kreft, \{Karim L.\} and Evert Verbraak and Wierenga-Wolf, \{Annet F.\} and \{van Meurs\}, Marjan and Oostra, \{Ben A.\} and Laman, \{Jon D.\} and Hintzen, \{Rogier Q.\}",

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T1 - The IL-7R alpha Pathway Is Quantitatively and Functionally Altered in CD8 T Cells in Multiple Sclerosis

AU - Kreft, Karim L.

AU - Verbraak, Evert

AU - Wierenga-Wolf, Annet F.

AU - van Meurs, Marjan

AU - Oostra, Ben A.

AU - Laman, Jon D.

AU - Hintzen, Rogier Q.

PY - 2012/2/15

Y1 - 2012/2/15

N2 - The IL-7R alpha single nucleotide polymorphism rs6897932 is associated with an increased risk for multiple sclerosis (MS). IL-7Ra is a promising candidate to be involved in autoimmunity, because it regulates T cell homeostasis, proliferation, and antiapoptotic signaling. However, the exact underlying mechanisms in the pathogenesis of MS are poorly understood. We investigated whether CD4 and CD8 lymphocyte subsets differed in IL-7R alpha expression and functionality in 78 MS patients compared with 59 healthy controls (HC). A significantly higher frequency of IL-7R alpha(+) CD8 effector memory (CD8EM) was found in MS. Moreover, IL-7R alpha membrane expression was significantly increased in MS in naive and memory CD8 (all p

AB - The IL-7R alpha single nucleotide polymorphism rs6897932 is associated with an increased risk for multiple sclerosis (MS). IL-7Ra is a promising candidate to be involved in autoimmunity, because it regulates T cell homeostasis, proliferation, and antiapoptotic signaling. However, the exact underlying mechanisms in the pathogenesis of MS are poorly understood. We investigated whether CD4 and CD8 lymphocyte subsets differed in IL-7R alpha expression and functionality in 78 MS patients compared with 59 healthy controls (HC). A significantly higher frequency of IL-7R alpha(+) CD8 effector memory (CD8EM) was found in MS. Moreover, IL-7R alpha membrane expression was significantly increased in MS in naive and memory CD8 (all p

KW - CENTRAL-NERVOUS-SYSTEM

KW - INTERLEUKIN-7 RECEPTOR

KW - RHEUMATOID-ARTHRITIS

KW - LYMPHOCYTE SUBSETS

KW - PERIPHERAL-BLOOD

KW - EXPRESSION

KW - RISK

KW - MEMORY

KW - LESIONS

KW - INFLAMMATION

U2 - 10.4049/jimmunol.1102559

DO - 10.4049/jimmunol.1102559

M3 - Article

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VL - 188

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JO - Journal of Immunology

JF - Journal of Immunology

IS - 4

ER -

The IL-7R alpha Pathway Is Quantitatively and Functionally Altered in CD8 T Cells in Multiple Sclerosis

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Keywords

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