The immunity-diet-microbiota axis in the development of metabolic syndrome

Eelke Brandsma, Tom Houben, Jingyuan Fu, Ronit Shiri-Sverdlov, Marten H. Hofker*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)

Abstract

Purpose of review

Recent evidence demonstrates that the gut-microbiota can be considered as one of the major factors causing metabolic and cardiovascular diseases.

Recent findings

Pattern recognition receptors as well as antimicrobial peptides are a key factor in controlling the intestinal microbiota composition. Deficiencies in these genes lead to changes in the composition of the gut-microbiota, causing leakage of endotoxins into the circulation, and the development of low-grade chronic inflammation and insulin resistance. Dietary composition can also affect the microbiota: a diet rich in saturated fats allows the expansion of pathobionts that damage the intestinal epithelial cell layer and compromise its barrier function. In contrast, a diet high in fiber supports the microbiota to produce short-chain fatty acids, thereby promoting energy expenditure and protecting against inflammation and insulin resistance.

Summary

The interactions between the microbiota, innate immunity, and diet play an important role in controlling metabolic homeostasis. A properly functioning innate immune system, combined with a low-fat and high-fiber diet, is important in preventing dysbiosis and reducing the susceptibility to developing the metabolic syndrome and its associated cardiovascular diseases.

Original languageEnglish
Pages (from-to)73-81
Number of pages9
JournalCurrent Opinion in Lipidology
Volume26
Issue number2
DOIs
Publication statusPublished - Apr-2015

Keywords

  • endotoxemia
  • innate immunity
  • metabolic syndrome
  • microbiota
  • short-chain fatty acids
  • CHAIN FATTY-ACIDS
  • GUT MICROBIOTA
  • INTESTINAL MICROBIOTA
  • INSULIN SENSITIVITY
  • RECEPTOR
  • MICE
  • PROMOTES
  • MUCOSAL
  • DYSBIOSIS
  • OBESITY

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