The impact of sleep deprivation on neuronal and glial signaling pathways important for memory and synaptic plasticity

Robbert Havekes, Christopher G Vecsey, Ted Abel

Research output: Contribution to journalReview articleAcademicpeer-review

109 Citations (Scopus)
46 Downloads (Pure)

Abstract

Sleep deprivation is a common feature in modern society, and one of the consequences of sleep loss is the impairment of cognitive function. Although it has been widely accepted that sleep deprivation affects learning and memory, only recently has research begun to address which molecular signaling pathways are altered by sleep loss and, more importantly, which pathways can be targeted to reverse the memory impairments resulting from sleep deprivation. In this review, we discuss the different methods used to sleep deprive animals and the effects of different durations of sleep deprivation on learning and memory with an emphasis on hippocampus-dependent memory. We then review the molecular signaling pathways that are sensitive to sleep loss, with a focus on those thought to play a critical role in the memory and synaptic plasticity deficits observed after sleep deprivation. Finally, we highlight several recent attempts to reverse the effects of sleep deprivation on memory and synaptic plasticity. Future research building on these studies promises to contribute to the development of novel strategies to ameliorate the effects of sleep loss on cognition.

Original languageEnglish
Pages (from-to)1251-1260
Number of pages10
JournalCellular Signalling
Volume24
Issue number6
DOIs
Publication statusPublished - Jun-2012
Externally publishedYes

Keywords

  • Animals
  • Cyclic AMP
  • Hippocampus
  • Humans
  • Memory
  • Neuroglia
  • Neuronal Plasticity
  • Neurons
  • Signal Transduction
  • Sleep Deprivation
  • Synapses
  • LONG-TERM POTENTIATION
  • BRAIN GENE-EXPRESSION
  • MORRIS WATER MAZE
  • CEREBRAL PROTEIN-SYNTHESIS
  • SPATIAL REFERENCE MEMORY
  • LOSS-INDUCED DEFICITS
  • LTP IN-VIVO
  • PARADOXICAL SLEEP
  • REM-SLEEP
  • RAT HIPPOCAMPUS

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