The induction of corticosteroid actions on membrane properties of hippocampal CA1 neurons requires protein synthesis

H KARST, M JOELS

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Abstract

Corticosterone can affect electrical properties of CA1 pyramidal neurons via binding to two corticoid receptor types, the mineralocorticoid (MR) and glucocorticoid receptor (GR). Previously we have shown that MR-activation leads to attenuation of serotonin (5-HT)-induced membrane hyperpolarization, while GR-activation induces an increase in the amplitude of the afterhyperpolarization (AHP) following a short current pulse. In this study we show that the MR- and GR-mediated changes of the membrane properties are prevented in the presence of the protein synthesis inhibitor cycloheximide, thus suggesting a genomic action of the steroids.

Original languageEnglish
Pages (from-to)27-31
Number of pages5
JournalNeuroscience Letters
Volume130
Issue number1
DOIs
Publication statusPublished - 2-Sep-1991

Keywords

  • CORTICOSTERONE
  • MINERALOCORTICOID RECEPTOR
  • GLUCOCORTICOID RECEPTOR
  • HIPPOCAMPUS
  • CA1
  • CYCLOHEXIMIDE
  • ELECTROPHYSIOLOGY
  • RAT-BRAIN
  • INVITRO
  • GLUCOCORTICOIDS
  • MODULATION
  • SEROTONIN
  • SLICES
  • STRESS

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