The influence of atrial fibrillation on the levels of NT-proBNP versus GDF-15 in patients with heart failure

Bernadet T Santema, Michelle M Y Chan, Jasper Tromp, Martin Dokter, Haye H van der Wal, Johanna E Emmens, Janny Takens, Nilesh J Samani, Leong L Ng, Chim C Lang, Peter van der Meer, Jozine M Ter Maaten, Kevin Damman, Kenneth Dickstein, John G Cleland, Faiez Zannad, Stefan D Anker, Marco Metra, Pim van der Harst, Rudolf A de BoerDirk J van Veldhuisen, Michiel Rienstra, Carolyn S P Lam, Adriaan A Voors

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Abstract

Background: In heart failure (HF), levels of NT-proBNP are influenced by the presence of concomitant atrial fibrillation (AF), making it difficult to distinguish between HF versus AF in patients with raised NT-proBNP. It is unknown whether levels of GDF-15 are also influenced by AF in patients with HF. In this study we compared the plasma levels of NT-proBNP versus GDF-15 in patients with HF in AF versus sinus rhythm (SR). Methods: In a post hoc analysis of the index cohort of BIOSTAT-CHF (n = 2516), we studied patients with HF categorized into three groups: (1) AF at baseline (n = 733), (2) SR at baseline with a history of AF (n = 183), and (3) SR at baseline and no history of AF (n = 1025). The findings were validated in the validation cohort of BIOSTAT-CHF (n = 1738). Results: Plasma NT-proBNP levels of patients who had AF at baseline were higher than those of patients in SR (both with and without a history of AF), even after multivariable adjustment (3417 [25th–75th percentile 1897–6486] versus 1788 [682–3870], adjusted p < 0.001, versus 2231 pg/mL [902–5270], adjusted p < 0.001). In contrast, after adjusting for clinical confounders, the levels of GDF-15 were comparable between the three groups (3179 [2062–5253] versus 2545 [1686–4337], adjusted p = 0.36, versus 2294 [1471–3855] pg/mL, adjusted p = 0.08). Similar patterns of both NT-proBNP and GDF-15 were found in the validation cohort. Conclusion: These data show that in patients with HF, NT-proBNP is significantly influenced by underlying AF at time of measurement and not by previous episodes of AF, whereas the levels of GDF-15 are not influenced by the presence of AF. Therefore, GDF-15 might have additive value combined with NT-proBNP in the assessment of patients with HF and concomitant AF. Graphic abstract: [Figure not available: see fulltext.].

Original languageEnglish
Pages (from-to)331-338
Number of pages8
JournalClinical Research in Cardiology
Volume109
Issue number3
Early online date1-Jul-2019
DOIs
Publication statusPublished - Mar-2020

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