The influence of low-grade glioma on resting state oscillatory brain activity: a magnetoencephalography study

I. Bosma; C. J. Stam; L. Douw; F. Bartolomei; J. J. Heimans; B. W. van Dijk; T. J. Postma; M. Klein; J. C. Reijneveld

doi:10.1007/s11060-008-9535-3

The influence of low-grade glioma on resting state oscillatory brain activity: a magnetoencephalography study

I. Bosma, C. J. Stam, L. Douw, F. Bartolomei, J. J. Heimans, B. W. van Dijk, T. J. Postma, M. Klein, J. C. Reijneveld

Research output: Contribution to journal › Article › Academic › peer-review

46 Citations (Scopus)

Abstract

PURPOSE: In the present MEG-study, power spectral analysis of oscillatory brain activity was used to compare resting state brain activity in both low-grade glioma (LGG) patients and healthy controls. We hypothesized that LGG patients show local as well as diffuse slowing of resting state brain activity compared to healthy controls and that particularly global slowing correlates with neurocognitive dysfunction.

PATIENT AND METHODS: Resting state MEG recordings were obtained from 17 LGG patients and 17 age-, sex-, and education-matched healthy controls. Relative spectral power was calculated in the delta, theta, upper and lower alpha, beta, and gamma frequency band. A battery of standardized neurocognitive tests measuring 6 neurocognitive domains was administered.

RESULTS: LGG patients showed a slowing of the resting state brain activity when compared to healthy controls. Decrease in relative power was mainly found in the gamma frequency band in the bilateral frontocentral MEG regions, whereas an increase in relative power was found in the theta frequency band in the left parietal region. An increase of the relative power in the theta and lower alpha band correlated with impaired executive functioning, information processing, and working memory.

CONCLUSION: LGG patients are characterized by global slowing of their resting state brain activity and this slowing phenomenon correlates with the observed neurocognitive deficits.

Original language	English
Pages (from-to)	77-85
Number of pages	9
Journal	Journal of Neuro-Oncology
Volume	88
Issue number	1
DOIs	https://doi.org/10.1007/s11060-008-9535-3
Publication status	Published - May-2008
Externally published	Yes

Keywords

Adult
Alpha Rhythm
Beta Rhythm
Brain
Brain Neoplasms
Cognition
Cognition Disorders
Delta Rhythm
Female
Functional Laterality
Glioma
Humans
Magnetoencephalography
Male
Memory, Short-Term
Mental Processes
Neuropsychological Tests
Parietal Lobe
Psychomotor Performance
Theta Rhythm
Journal Article
Research Support, Non-U.S. Gov't

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title = "The influence of low-grade glioma on resting state oscillatory brain activity: a magnetoencephalography study",

abstract = "PURPOSE: In the present MEG-study, power spectral analysis of oscillatory brain activity was used to compare resting state brain activity in both low-grade glioma (LGG) patients and healthy controls. We hypothesized that LGG patients show local as well as diffuse slowing of resting state brain activity compared to healthy controls and that particularly global slowing correlates with neurocognitive dysfunction.PATIENT AND METHODS: Resting state MEG recordings were obtained from 17 LGG patients and 17 age-, sex-, and education-matched healthy controls. Relative spectral power was calculated in the delta, theta, upper and lower alpha, beta, and gamma frequency band. A battery of standardized neurocognitive tests measuring 6 neurocognitive domains was administered.RESULTS: LGG patients showed a slowing of the resting state brain activity when compared to healthy controls. Decrease in relative power was mainly found in the gamma frequency band in the bilateral frontocentral MEG regions, whereas an increase in relative power was found in the theta frequency band in the left parietal region. An increase of the relative power in the theta and lower alpha band correlated with impaired executive functioning, information processing, and working memory.CONCLUSION: LGG patients are characterized by global slowing of their resting state brain activity and this slowing phenomenon correlates with the observed neurocognitive deficits.",

keywords = "Adult, Alpha Rhythm, Beta Rhythm, Brain, Brain Neoplasms, Cognition, Cognition Disorders, Delta Rhythm, Female, Functional Laterality, Glioma, Humans, Magnetoencephalography, Male, Memory, Short-Term, Mental Processes, Neuropsychological Tests, Parietal Lobe, Psychomotor Performance, Theta Rhythm, Journal Article, Research Support, Non-U.S. Gov't",

author = "I. Bosma and Stam, {C. J.} and L. Douw and F. Bartolomei and Heimans, {J. J.} and {van Dijk}, {B. W.} and Postma, {T. J.} and M. Klein and Reijneveld, {J. C.}",

year = "2008",

month = may,

doi = "10.1007/s11060-008-9535-3",

language = "English",

volume = "88",

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T1 - The influence of low-grade glioma on resting state oscillatory brain activity

T2 - a magnetoencephalography study

AU - Bosma, I.

AU - Stam, C. J.

AU - Douw, L.

AU - Bartolomei, F.

AU - Heimans, J. J.

AU - van Dijk, B. W.

AU - Postma, T. J.

AU - Klein, M.

AU - Reijneveld, J. C.

PY - 2008/5

Y1 - 2008/5

N2 - PURPOSE: In the present MEG-study, power spectral analysis of oscillatory brain activity was used to compare resting state brain activity in both low-grade glioma (LGG) patients and healthy controls. We hypothesized that LGG patients show local as well as diffuse slowing of resting state brain activity compared to healthy controls and that particularly global slowing correlates with neurocognitive dysfunction.PATIENT AND METHODS: Resting state MEG recordings were obtained from 17 LGG patients and 17 age-, sex-, and education-matched healthy controls. Relative spectral power was calculated in the delta, theta, upper and lower alpha, beta, and gamma frequency band. A battery of standardized neurocognitive tests measuring 6 neurocognitive domains was administered.RESULTS: LGG patients showed a slowing of the resting state brain activity when compared to healthy controls. Decrease in relative power was mainly found in the gamma frequency band in the bilateral frontocentral MEG regions, whereas an increase in relative power was found in the theta frequency band in the left parietal region. An increase of the relative power in the theta and lower alpha band correlated with impaired executive functioning, information processing, and working memory.CONCLUSION: LGG patients are characterized by global slowing of their resting state brain activity and this slowing phenomenon correlates with the observed neurocognitive deficits.

AB - PURPOSE: In the present MEG-study, power spectral analysis of oscillatory brain activity was used to compare resting state brain activity in both low-grade glioma (LGG) patients and healthy controls. We hypothesized that LGG patients show local as well as diffuse slowing of resting state brain activity compared to healthy controls and that particularly global slowing correlates with neurocognitive dysfunction.PATIENT AND METHODS: Resting state MEG recordings were obtained from 17 LGG patients and 17 age-, sex-, and education-matched healthy controls. Relative spectral power was calculated in the delta, theta, upper and lower alpha, beta, and gamma frequency band. A battery of standardized neurocognitive tests measuring 6 neurocognitive domains was administered.RESULTS: LGG patients showed a slowing of the resting state brain activity when compared to healthy controls. Decrease in relative power was mainly found in the gamma frequency band in the bilateral frontocentral MEG regions, whereas an increase in relative power was found in the theta frequency band in the left parietal region. An increase of the relative power in the theta and lower alpha band correlated with impaired executive functioning, information processing, and working memory.CONCLUSION: LGG patients are characterized by global slowing of their resting state brain activity and this slowing phenomenon correlates with the observed neurocognitive deficits.

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KW - Beta Rhythm

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KW - Brain Neoplasms

KW - Cognition

KW - Cognition Disorders

KW - Delta Rhythm

KW - Female

KW - Functional Laterality

KW - Glioma

KW - Humans

KW - Magnetoencephalography

KW - Male

KW - Memory, Short-Term

KW - Mental Processes

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KW - Parietal Lobe

KW - Psychomotor Performance

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JO - Journal of Neuro-Oncology

JF - Journal of Neuro-Oncology

IS - 1

ER -

The influence of low-grade glioma on resting state oscillatory brain activity: a magnetoencephalography study

Abstract

Keywords

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