The influence of pregnancy and gender on perivascular innervation of rat posterior cerebral arteries

Annet M. Aukes, Nicole Bishop, Julie Godfrey, Marilyn J. Cipolla*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    13 Citations (Scopus)

    Abstract

    The authors investigated the influence of pregnancy and gender on the density of trigeminal and sympathetic perivascular nerves in posterior cerebral arteries (PCA) and the reactivity to norepinephrine and calcitonin gene-related peptide (CGRP). PCAs were isolated from nonpregnant, late-pregnant, postpartum, and male rats, mounted and pressurized on an arteriograph chamber to obtain concentration-response curves to norepinephrine and CGRP. Arteries were immunostained for CGRP-, tyrosine hydroxylase, and protein gene product 9.5 (PGP 9.5)-containing perivascular nerves, and nerve density was determined morphologically. Pregnancy had a trophic effect on trigeminal perivascular innervation (P

    Original languageEnglish
    Pages (from-to)411-419
    Number of pages9
    JournalReproductive Sciences
    Volume15
    Issue number4
    DOIs
    Publication statusPublished - Apr-2008

    Keywords

    • perivascular innervation
    • pial arteries
    • pregnancy
    • rat
    • GENE-RELATED PEPTIDE
    • SEX STEROID-HORMONES
    • DORSAL-ROOT GANGLIA
    • SYMPATHETIC-NERVES
    • BLOOD-VESSELS
    • HYPERTENSION
    • MIGRAINE
    • ECLAMPSIA
    • PATHOPHYSIOLOGY
    • CIRCULATION

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