The integrative value of myocardial perfusion-function imaging with 13N-ammonia positron emission tomography: From methodology to clinical impact

Luis Eduardo Juárez Orozco

    Research output: ThesisThesis fully internal (DIV)

    805 Downloads (Pure)


    The current profile of cardiovascular disease is a source of concern due to its prevalence and the substantial burden of its associated outcomes. Although advances in cardiac therapy represent a great contribution in this area, there is a need for better and more integral methods to diagnose and evaluate prognosis in patients with heart disease. Within these novel state-of-the-art methods, the present thesis studied the utilization of positron emission tomography (PET) imaging using 13N-ammonia (an injectable tracer that allows us to picture blood flow in the coronary arteries).
    By exploring alternatives in methodological aspects of this technique as well as how blood flow and heart motion relate to each other in different groups of patients, we propose that further integration of clinical data and data obtained through PET should be considered when characterizing heart disease. We confirmed the relevant influence of diabetes mellitus as a risk factor that affects not only heart blood flow but heart motion as well. In the near future, the combination of measurements obtained by cardiac PET imaging may optimize risk stratification as they already translate an elevated risk of fatal outcomes individually.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    • Dierckx, Rudi, Supervisor
    • Alexanderson-Rosas, Erick, Supervisor, External person
    • Slart, Riemer, Supervisor
    • Tio, Rene, Co-supervisor
    Award date16-Jan-2017
    Place of Publication[Groningen]
    Print ISBNs978-90-367-9476-3
    Electronic ISBNs978-90-367-9475-6
    Publication statusPublished - 2017

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