The International Testicular Cancer Linkage Consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred

Phuong L. Mai*, Michael Friedlander, Kathy Tucker, Kelly-Anne Phillips, David Hogg, Michael A. S. Jewett, Radka Lohynska, Gedske Daugaard, Stephane Richard, Catherine Bonaiti-Pellie, Axel Heidenreich, Peter Albers, Istvan Bodrogi, Lajos Geczi, Edith Olah, Peter A. Daly, Parry Guilford, Sophie D. Fossa, Ketil Heimdal, Ludmila LiubchenkoSergei A. Tjulandin, Hans Stoll, Walter Weber, Douglas F. Easton, Darshna Dudakia, Robert Huddart, Michael R. Stratton, Lawrence Einhorn, Larissa Korde, Katherine L. Nathanson, Timothy Bishop, Elizabeth A. Rapley, Mark H. Greene

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)

Abstract

Objectives: Familial aggregation of testicular germ cell tumor (TGCT) has been reported, but it is unclear if familial TGCT represents a unique entity with distinct clinicopathologic characteristics. Here we describe a collection of familial TGCT cases from an international consortium, in an effort to elucidate any clinical characteristics that are specific to this population.

Materials and methods: Families with >= 2 cases of TGCT enrolled at 18 of the sites participating in the International Testicular Cancer Linkage Consortium were included. We analyzed clinicopathologic characteristics of 985 cases from 461 families.

Results: A majority (88.5%) of families had only 2 cases of TGCT. Men with seminoma (50% of cases) had an older mean age at diagnosis than nonseminoma cases (P = 0.001). Among individuals with a history of cryptorchidism. TGCT was more likely to occur in the ipsilateral testis (kappa = 0.65). Cousin pairs appeared to represent a unique group, with younger age at diagnosis and a higher prevalence of cryptorchidism than other families.

Conclusions: Clinicopathologic characteristics in these familial TGCT cases were similar to those generally described for nonfamilial eases. However, we observed a unique presentation of familial TGCT among cousin pairs. Additional studies are needed to further explore this observation. Published by Elsevier Inc.

Original languageEnglish
Pages (from-to)492-499
Number of pages8
JournalUrologic Oncology-Seminars and Original Investigations
Volume28
Issue number5
DOIs
Publication statusPublished - 2010

Keywords

  • Testicular neoplasms
  • Familial
  • Epidemiology
  • Clinicopathologic characteristics
  • OF-THE-LITERATURE
  • SUSCEPTIBILITY GENES
  • RISK-FACTORS
  • EXPERIENCE
  • ANTICIPATION
  • EPIDEMIOLOGY
  • POPULATION
  • TESTIS
  • FATHER

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