The International Testicular Cancer Linkage Consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred

Phuong L. Mai; Michael Friedlander; Kathy Tucker; Kelly-Anne Phillips; David Hogg; Michael A. S. Jewett; Radka Lohynska; Gedske Daugaard; Stephane Richard; Catherine Bonaiti-Pellie; Axel Heidenreich; Peter Albers; Istvan Bodrogi; Lajos Geczi; Edith Olah; Peter A. Daly; Parry Guilford; Sophie D. Fossa; Ketil Heimdal; Ludmila Liubchenko; Sergei A. Tjulandin; Hans Stoll; Walter Weber; Douglas F. Easton; Darshna Dudakia; Robert Huddart; Michael R. Stratton; Lawrence Einhorn; Larissa Korde; Katherine L. Nathanson; Timothy Bishop; Elizabeth A. Rapley; Mark H. Greene

doi:10.1016/j.urolonc.2008.10.004

The International Testicular Cancer Linkage Consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred

Phuong L. Mai^*, Michael Friedlander, Kathy Tucker, Kelly-Anne Phillips, David Hogg, Michael A. S. Jewett, Radka Lohynska, Gedske Daugaard, Stephane Richard, Catherine Bonaiti-Pellie, Axel Heidenreich, Peter Albers, Istvan Bodrogi, Lajos Geczi, Edith Olah, Peter A. Daly, Parry Guilford, Sophie D. Fossa, Ketil Heimdal, Ludmila LiubchenkoSergei A. Tjulandin, Hans Stoll, Walter Weber, Douglas F. Easton, Darshna Dudakia, Robert Huddart, Michael R. Stratton, Lawrence Einhorn, Larissa Korde, Katherine L. Nathanson, Timothy Bishop, Elizabeth A. Rapley, Mark H. Greene

^*Corresponding author for this work

University of Groningen

Research output: Contribution to journal › Article › Academic › peer-review

33 Citations (Scopus)

Abstract

Objectives: Familial aggregation of testicular germ cell tumor (TGCT) has been reported, but it is unclear if familial TGCT represents a unique entity with distinct clinicopathologic characteristics. Here we describe a collection of familial TGCT cases from an international consortium, in an effort to elucidate any clinical characteristics that are specific to this population.

Materials and methods: Families with >= 2 cases of TGCT enrolled at 18 of the sites participating in the International Testicular Cancer Linkage Consortium were included. We analyzed clinicopathologic characteristics of 985 cases from 461 families.

Results: A majority (88.5%) of families had only 2 cases of TGCT. Men with seminoma (50% of cases) had an older mean age at diagnosis than nonseminoma cases (P = 0.001). Among individuals with a history of cryptorchidism. TGCT was more likely to occur in the ipsilateral testis (kappa = 0.65). Cousin pairs appeared to represent a unique group, with younger age at diagnosis and a higher prevalence of cryptorchidism than other families.

Conclusions: Clinicopathologic characteristics in these familial TGCT cases were similar to those generally described for nonfamilial eases. However, we observed a unique presentation of familial TGCT among cousin pairs. Additional studies are needed to further explore this observation. Published by Elsevier Inc.

Original language	English
Pages (from-to)	492-499
Number of pages	8
Journal	Urologic Oncology-Seminars and Original Investigations
Volume	28
Issue number	5
DOIs	https://doi.org/10.1016/j.urolonc.2008.10.004
Publication status	Published - 2010

Keywords

Testicular neoplasms
Familial
Epidemiology
Clinicopathologic characteristics
OF-THE-LITERATURE
SUSCEPTIBILITY GENES
RISK-FACTORS
EXPERIENCE
ANTICIPATION
EPIDEMIOLOGY
POPULATION
TESTIS
FATHER

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Mai, P. L., Friedlander, M., Tucker, K., Phillips, K-A., Hogg, D., Jewett, M. A. S., Lohynska, R., Daugaard, G., Richard, S., Bonaiti-Pellie, C., Heidenreich, A., Albers, P., Bodrogi, I., Geczi, L., Olah, E., Daly, P. A., Guilford, P., Fossa, S. D., Heimdal, K., ... Greene, M. H. (2010). The International Testicular Cancer Linkage Consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred. Urologic Oncology-Seminars and Original Investigations, 28(5), 492-499. https://doi.org/10.1016/j.urolonc.2008.10.004

@article{3dede084adac43fe96c50a234c4dbb57,

title = "The International Testicular Cancer Linkage Consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred",

abstract = "Objectives: Familial aggregation of testicular germ cell tumor (TGCT) has been reported, but it is unclear if familial TGCT represents a unique entity with distinct clinicopathologic characteristics. Here we describe a collection of familial TGCT cases from an international consortium, in an effort to elucidate any clinical characteristics that are specific to this population.Materials and methods: Families with >= 2 cases of TGCT enrolled at 18 of the sites participating in the International Testicular Cancer Linkage Consortium were included. We analyzed clinicopathologic characteristics of 985 cases from 461 families.Results: A majority (88.5%) of families had only 2 cases of TGCT. Men with seminoma (50% of cases) had an older mean age at diagnosis than nonseminoma cases (P = 0.001). Among individuals with a history of cryptorchidism. TGCT was more likely to occur in the ipsilateral testis (kappa = 0.65). Cousin pairs appeared to represent a unique group, with younger age at diagnosis and a higher prevalence of cryptorchidism than other families.Conclusions: Clinicopathologic characteristics in these familial TGCT cases were similar to those generally described for nonfamilial eases. However, we observed a unique presentation of familial TGCT among cousin pairs. Additional studies are needed to further explore this observation. Published by Elsevier Inc.",

keywords = "Testicular neoplasms, Familial, Epidemiology, Clinicopathologic characteristics, OF-THE-LITERATURE, SUSCEPTIBILITY GENES, RISK-FACTORS, EXPERIENCE, ANTICIPATION, EPIDEMIOLOGY, POPULATION, TESTIS, FATHER",

author = "Mai, {Phuong L.} and Michael Friedlander and Kathy Tucker and Kelly-Anne Phillips and David Hogg and Jewett, {Michael A. S.} and Radka Lohynska and Gedske Daugaard and Stephane Richard and Catherine Bonaiti-Pellie and Axel Heidenreich and Peter Albers and Istvan Bodrogi and Lajos Geczi and Edith Olah and Daly, {Peter A.} and Parry Guilford and Fossa, {Sophie D.} and Ketil Heimdal and Ludmila Liubchenko and Tjulandin, {Sergei A.} and Hans Stoll and Walter Weber and Easton, {Douglas F.} and Darshna Dudakia and Robert Huddart and Stratton, {Michael R.} and Lawrence Einhorn and Larissa Korde and Nathanson, {Katherine L.} and Timothy Bishop and Rapley, {Elizabeth A.} and Greene, {Mark H.}",

year = "2010",

doi = "10.1016/j.urolonc.2008.10.004",

language = "English",

volume = "28",

pages = "492--499",

journal = "Urologic Oncology-Seminars and Original Investigations",

issn = "1078-1439",

publisher = "ELSEVIER SCIENCE INC",

number = "5",

}

Mai, PL, Friedlander, M, Tucker, K, Phillips, K-A, Hogg, D, Jewett, MAS, Lohynska, R, Daugaard, G, Richard, S, Bonaiti-Pellie, C, Heidenreich, A, Albers, P, Bodrogi, I, Geczi, L, Olah, E, Daly, PA, Guilford, P, Fossa, SD, Heimdal, K, Liubchenko, L, Tjulandin, SA, Stoll, H, Weber, W, Easton, DF, Dudakia, D, Huddart, R, Stratton, MR, Einhorn, L, Korde, L, Nathanson, KL, Bishop, T, Rapley, EA & Greene, MH 2010, 'The International Testicular Cancer Linkage Consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred', Urologic Oncology-Seminars and Original Investigations, vol. 28, no. 5, pp. 492-499. https://doi.org/10.1016/j.urolonc.2008.10.004

The International Testicular Cancer Linkage Consortium : A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred. / Mai, Phuong L.; Friedlander, Michael; Tucker, Kathy et al.

In: Urologic Oncology-Seminars and Original Investigations, Vol. 28, No. 5, 2010, p. 492-499.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The International Testicular Cancer Linkage Consortium

T2 - A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred

AU - Mai, Phuong L.

AU - Friedlander, Michael

AU - Tucker, Kathy

AU - Phillips, Kelly-Anne

AU - Hogg, David

AU - Jewett, Michael A. S.

AU - Lohynska, Radka

AU - Daugaard, Gedske

AU - Richard, Stephane

AU - Bonaiti-Pellie, Catherine

AU - Heidenreich, Axel

AU - Albers, Peter

AU - Bodrogi, Istvan

AU - Geczi, Lajos

AU - Olah, Edith

AU - Daly, Peter A.

AU - Guilford, Parry

AU - Fossa, Sophie D.

AU - Heimdal, Ketil

AU - Liubchenko, Ludmila

AU - Tjulandin, Sergei A.

AU - Stoll, Hans

AU - Weber, Walter

AU - Easton, Douglas F.

AU - Dudakia, Darshna

AU - Huddart, Robert

AU - Stratton, Michael R.

AU - Einhorn, Lawrence

AU - Korde, Larissa

AU - Nathanson, Katherine L.

AU - Bishop, Timothy

AU - Rapley, Elizabeth A.

AU - Greene, Mark H.

PY - 2010

Y1 - 2010

N2 - Objectives: Familial aggregation of testicular germ cell tumor (TGCT) has been reported, but it is unclear if familial TGCT represents a unique entity with distinct clinicopathologic characteristics. Here we describe a collection of familial TGCT cases from an international consortium, in an effort to elucidate any clinical characteristics that are specific to this population.Materials and methods: Families with >= 2 cases of TGCT enrolled at 18 of the sites participating in the International Testicular Cancer Linkage Consortium were included. We analyzed clinicopathologic characteristics of 985 cases from 461 families.Results: A majority (88.5%) of families had only 2 cases of TGCT. Men with seminoma (50% of cases) had an older mean age at diagnosis than nonseminoma cases (P = 0.001). Among individuals with a history of cryptorchidism. TGCT was more likely to occur in the ipsilateral testis (kappa = 0.65). Cousin pairs appeared to represent a unique group, with younger age at diagnosis and a higher prevalence of cryptorchidism than other families.Conclusions: Clinicopathologic characteristics in these familial TGCT cases were similar to those generally described for nonfamilial eases. However, we observed a unique presentation of familial TGCT among cousin pairs. Additional studies are needed to further explore this observation. Published by Elsevier Inc.

AB - Objectives: Familial aggregation of testicular germ cell tumor (TGCT) has been reported, but it is unclear if familial TGCT represents a unique entity with distinct clinicopathologic characteristics. Here we describe a collection of familial TGCT cases from an international consortium, in an effort to elucidate any clinical characteristics that are specific to this population.Materials and methods: Families with >= 2 cases of TGCT enrolled at 18 of the sites participating in the International Testicular Cancer Linkage Consortium were included. We analyzed clinicopathologic characteristics of 985 cases from 461 families.Results: A majority (88.5%) of families had only 2 cases of TGCT. Men with seminoma (50% of cases) had an older mean age at diagnosis than nonseminoma cases (P = 0.001). Among individuals with a history of cryptorchidism. TGCT was more likely to occur in the ipsilateral testis (kappa = 0.65). Cousin pairs appeared to represent a unique group, with younger age at diagnosis and a higher prevalence of cryptorchidism than other families.Conclusions: Clinicopathologic characteristics in these familial TGCT cases were similar to those generally described for nonfamilial eases. However, we observed a unique presentation of familial TGCT among cousin pairs. Additional studies are needed to further explore this observation. Published by Elsevier Inc.

KW - Testicular neoplasms

KW - Familial

KW - Epidemiology

KW - Clinicopathologic characteristics

KW - OF-THE-LITERATURE

KW - SUSCEPTIBILITY GENES

KW - RISK-FACTORS

KW - EXPERIENCE

KW - ANTICIPATION

KW - EPIDEMIOLOGY

KW - POPULATION

KW - TESTIS

KW - FATHER

U2 - 10.1016/j.urolonc.2008.10.004

DO - 10.1016/j.urolonc.2008.10.004

M3 - Article

VL - 28

SP - 492

EP - 499

JO - Urologic Oncology-Seminars and Original Investigations

JF - Urologic Oncology-Seminars and Original Investigations

SN - 1078-1439

IS - 5

ER -