The link between callous-unemotional traits and neural mechanisms of reward processing: An fMRI study

Kim Veroude; Daniel von Rhein; Roselyne J. M. Chauvin; Eelco V. van Dongen; Maarten J. J. Mennes; Barbara Franke; Dirk J. Heslenfeld; Jaap Oosterlaan; Catharina A. Hartman; Pieter J. Hoekstra; Jeffrey C. Glennon; Jan K. Buitelaar

doi:10.1016/j.pscychresns.2016.08.005

The link between callous-unemotional traits and neural mechanisms of reward processing: An fMRI study

Kim Veroude^*
, Daniel von Rhein
, Roselyne J. M. Chauvin
, Eelco V. van Dongen
, Maarten J. J. Mennes
, Barbara Franke
, Dirk J. Heslenfeld
, Jaap Oosterlaan
, Catharina A. Hartman
, Pieter J. Hoekstra
, Jeffrey C. Glennon
, Jan K. Buitelaar

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

37 Citations (Scopus)

130 Downloads (Pure)

Abstract

Callous-unemotional (CU) traits, i.e., unconcernedness and lack of prosocial feelings, may manifest in Conduct Disorder (CD), but also in Oppositional Defiant Disorder (ODD) and Attention Deficit Hyperactivity Disorder (ADHD). These disorders have been associated with aberrant reward processing, while the influence of CU traits is unclear. Using functional Magnetic Resonance Imaging (fMRI), we examined whether CU traits affect the neural circuit for reward. A Monetary Incentive Delay (MID) task was administered to 328 adolescents and young adults with varying levels of CU traits: 40 participants with ODD/CD plus ADHD, 101 participants with ADHD only, 84 siblings of probands with ADHD and 103 typically developing (TD) individuals. During reward anticipation, CU traits related negatively to medial prefrontal cortex (mPFC) activity, independent of ADHD symptoms and ODD/CD diagnosis. Our results indicate that CU traits are a valuable dimension for assessing the neural basis of reward processing. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	75-80
Number of pages	6
Journal	Psychiatry research: Neuroimaging
Volume	255
DOIs	https://doi.org/10.1016/j.pscychresns.2016.08.005
Publication status	Published - 30-Sept-2016

Keywords

ADHD
CD
Psychopathy
Brain
mPFC
ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
VENTROMEDIAL PREFRONTAL CORTEX
PSYCHOPATHIC TRAITS
CONDUCT DISORDER
ANTISOCIAL-BEHAVIOR
DISRUPTIVE BEHAVIOR
UNAFFECTED SIBLINGS
TASK DESIGN
ANTICIPATION
CHILDREN

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Veroude, K., von Rhein, D., Chauvin, R. J. M., van Dongen, E. V., Mennes, M. J. J., Franke, B., Heslenfeld, D. J., Oosterlaan, J., Hartman, C. A., Hoekstra, P. J., Glennon, J. C., & Buitelaar, J. K. (2016). The link between callous-unemotional traits and neural mechanisms of reward processing: An fMRI study. Psychiatry research: Neuroimaging, 255, 75-80. https://doi.org/10.1016/j.pscychresns.2016.08.005

@article{2afd6513299f4e8cabb8633be53c7338,

title = "The link between callous-unemotional traits and neural mechanisms of reward processing: An fMRI study",

abstract = "Callous-unemotional (CU) traits, i.e., unconcernedness and lack of prosocial feelings, may manifest in Conduct Disorder (CD), but also in Oppositional Defiant Disorder (ODD) and Attention Deficit Hyperactivity Disorder (ADHD). These disorders have been associated with aberrant reward processing, while the influence of CU traits is unclear. Using functional Magnetic Resonance Imaging (fMRI), we examined whether CU traits affect the neural circuit for reward. A Monetary Incentive Delay (MID) task was administered to 328 adolescents and young adults with varying levels of CU traits: 40 participants with ODD/CD plus ADHD, 101 participants with ADHD only, 84 siblings of probands with ADHD and 103 typically developing (TD) individuals. During reward anticipation, CU traits related negatively to medial prefrontal cortex (mPFC) activity, independent of ADHD symptoms and ODD/CD diagnosis. Our results indicate that CU traits are a valuable dimension for assessing the neural basis of reward processing. (C) 2016 Elsevier Ireland Ltd. All rights reserved.",

keywords = "ADHD, CD, Psychopathy, Brain, mPFC, ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, VENTROMEDIAL PREFRONTAL CORTEX, PSYCHOPATHIC TRAITS, CONDUCT DISORDER, ANTISOCIAL-BEHAVIOR, DISRUPTIVE BEHAVIOR, UNAFFECTED SIBLINGS, TASK DESIGN, ANTICIPATION, CHILDREN",

author = "Kim Veroude and \{von Rhein\}, Daniel and Chauvin, \{Roselyne J. M.\} and \{van Dongen\}, \{Eelco V.\} and Mennes, \{Maarten J. J.\} and Barbara Franke and Heslenfeld, \{Dirk J.\} and Jaap Oosterlaan and Hartman, \{Catharina A.\} and Hoekstra, \{Pieter J.\} and Glennon, \{Jeffrey C.\} and Buitelaar, \{Jan K.\}",

year = "2016",

month = sep,

day = "30",

doi = "10.1016/j.pscychresns.2016.08.005",

language = "English",

volume = "255",

pages = "75--80",

journal = "Psychiatry research: Neuroimaging",

issn = "0925-4927",

publisher = "ELSEVIER IRELAND LTD",

}

Veroude, K, von Rhein, D, Chauvin, RJM, van Dongen, EV, Mennes, MJJ, Franke, B, Heslenfeld, DJ, Oosterlaan, J, Hartman, CA , Hoekstra, PJ, Glennon, JC & Buitelaar, JK 2016, 'The link between callous-unemotional traits and neural mechanisms of reward processing: An fMRI study', Psychiatry research: Neuroimaging, vol. 255, pp. 75-80. https://doi.org/10.1016/j.pscychresns.2016.08.005

TY - JOUR

T1 - The link between callous-unemotional traits and neural mechanisms of reward processing

T2 - An fMRI study

AU - Veroude, Kim

AU - von Rhein, Daniel

AU - Chauvin, Roselyne J. M.

AU - van Dongen, Eelco V.

AU - Mennes, Maarten J. J.

AU - Franke, Barbara

AU - Heslenfeld, Dirk J.

AU - Oosterlaan, Jaap

AU - Hartman, Catharina A.

AU - Hoekstra, Pieter J.

AU - Glennon, Jeffrey C.

AU - Buitelaar, Jan K.

PY - 2016/9/30

Y1 - 2016/9/30

N2 - Callous-unemotional (CU) traits, i.e., unconcernedness and lack of prosocial feelings, may manifest in Conduct Disorder (CD), but also in Oppositional Defiant Disorder (ODD) and Attention Deficit Hyperactivity Disorder (ADHD). These disorders have been associated with aberrant reward processing, while the influence of CU traits is unclear. Using functional Magnetic Resonance Imaging (fMRI), we examined whether CU traits affect the neural circuit for reward. A Monetary Incentive Delay (MID) task was administered to 328 adolescents and young adults with varying levels of CU traits: 40 participants with ODD/CD plus ADHD, 101 participants with ADHD only, 84 siblings of probands with ADHD and 103 typically developing (TD) individuals. During reward anticipation, CU traits related negatively to medial prefrontal cortex (mPFC) activity, independent of ADHD symptoms and ODD/CD diagnosis. Our results indicate that CU traits are a valuable dimension for assessing the neural basis of reward processing. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

AB - Callous-unemotional (CU) traits, i.e., unconcernedness and lack of prosocial feelings, may manifest in Conduct Disorder (CD), but also in Oppositional Defiant Disorder (ODD) and Attention Deficit Hyperactivity Disorder (ADHD). These disorders have been associated with aberrant reward processing, while the influence of CU traits is unclear. Using functional Magnetic Resonance Imaging (fMRI), we examined whether CU traits affect the neural circuit for reward. A Monetary Incentive Delay (MID) task was administered to 328 adolescents and young adults with varying levels of CU traits: 40 participants with ODD/CD plus ADHD, 101 participants with ADHD only, 84 siblings of probands with ADHD and 103 typically developing (TD) individuals. During reward anticipation, CU traits related negatively to medial prefrontal cortex (mPFC) activity, independent of ADHD symptoms and ODD/CD diagnosis. Our results indicate that CU traits are a valuable dimension for assessing the neural basis of reward processing. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

KW - ADHD

KW - CD

KW - Psychopathy

KW - Brain

KW - mPFC

KW - ATTENTION-DEFICIT/HYPERACTIVITY DISORDER

KW - VENTROMEDIAL PREFRONTAL CORTEX

KW - PSYCHOPATHIC TRAITS

KW - CONDUCT DISORDER

KW - ANTISOCIAL-BEHAVIOR

KW - DISRUPTIVE BEHAVIOR

KW - UNAFFECTED SIBLINGS

KW - TASK DESIGN

KW - ANTICIPATION

KW - CHILDREN

U2 - 10.1016/j.pscychresns.2016.08.005

DO - 10.1016/j.pscychresns.2016.08.005

M3 - Article

C2 - 27564545

SN - 0925-4927

VL - 255

SP - 75

EP - 80

JO - Psychiatry research: Neuroimaging

JF - Psychiatry research: Neuroimaging

ER -

The link between callous-unemotional traits and neural mechanisms of reward processing: An fMRI study

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Keywords

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