The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease

International COVID-19 Airways Diseases Group, Davies Adeloye, Omer Elneima, Luke Daines, Krisnah Poinasamy, Jennifer K. Quint, Samantha Walker, Chris E. Brightling, Salman Siddiqui, John R. Hurst, James D. Chalmers, Paul E. Pfeffer, Petr Novotny, Thomas M. Drake, Liam G. Heaney, Igor Rudan, Aziz Sheikh, Anthony De Soyza*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

69 Citations (Scopus)


Persistent ill health after acute COVID-19—referred to as long COVID, the post-acute COVID-19 syndrome, or the post-COVID-19 condition—has emerged as a major concern. We undertook an international consensus exercise to identify research priorities with the aim of understanding the long-term effects of acute COVID-19, with a focus on people with pre-existing airways disease and the occurrence of new-onset airways disease and associated symptoms. 202 international experts were invited to submit a minimum of three research ideas. After a two-phase internal review process, a final list of 98 research topics was scored by 48 experts. Patients with pre-existing or post-COVID-19 airways disease contributed to the exercise by weighting selected criteria. The highest-ranked research idea focused on investigation of the relationship between prognostic scores at hospital admission and morbidity at 3 months and 12 months after hospital discharge in patients with and without pre-existing airways disease. High priority was also assigned to comparisons of the prevalence and severity of post-COVID-19 fatigue, sarcopenia, anxiety, depression, and risk of future cardiovascular complications in patients with and without pre-existing airways disease. Our approach has enabled development of a set of priorities that could inform future research studies and funding decisions. This prioritisation process could also be adapted to other, non-respiratory aspects of long COVID.

Original languageEnglish
Pages (from-to)1467-1478
Number of pages12
JournalThe Lancet Respiratory Medicine
Issue number12
Publication statusPublished - Dec-2021

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