Abstract
Telomeres are essential for genomic integrity, but little is known about their regulation in the normal human mammary gland. We now demonstrate that a phenotypically defined cell population enriched in luminal progenitors (LPs) is characterized by unusually short telomeres independently of donor age. Furthermore, we find that multiple DNA damage response proteins colocalize with telomeres in >95% of LPs but in
Original language | English |
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Pages (from-to) | 28-37 |
Number of pages | 10 |
Journal | Stem Cell Reports |
Volume | 1 |
Issue number | 1 |
DOIs | |
Publication status | Published - 4-Jun-2013 |
Keywords
- EPITHELIAL-CELLS
- FLOW-CYTOMETRY
- CANCER-CELLS
- MRN COMPLEX
- DNA-DAMAGE
- STEM-CELLS
- LENGTH
- EXPRESSION
- REPAIR
- ASSOCIATION