The Luminal Progenitor Compartment of the Normal Human Mammary Gland Constitutes a Unique Site of Telomere Dysfunction

Nagarajan Kannan; Nazmul Huda; LiRen Tu; Radina Droumeva; Geraldine Aubert; Elizabeth Chavez; Ryan R. Brinkman; Peter Lansdorp; Joanne Emerman; Satoshi Abe; Connie Eaves; David Gilley

doi:10.1016/j.stemcr.2013.04.003

The Luminal Progenitor Compartment of the Normal Human Mammary Gland Constitutes a Unique Site of Telomere Dysfunction

Nagarajan Kannan, Nazmul Huda, LiRen Tu, Radina Droumeva, Geraldine Aubert, Elizabeth Chavez, Ryan R. Brinkman, Peter Lansdorp, Joanne Emerman, Satoshi Abe, Connie Eaves^*, David Gilley

^*Corresponding author for this work

Damage and Repair in Cancer Development and Cancer Treatment (DARE)

Research output: Contribution to journal › Article › Academic › peer-review

38 Citations (Scopus)

182 Downloads (Pure)

Abstract

Telomeres are essential for genomic integrity, but little is known about their regulation in the normal human mammary gland. We now demonstrate that a phenotypically defined cell population enriched in luminal progenitors (LPs) is characterized by unusually short telomeres independently of donor age. Furthermore, we find that multiple DNA damage response proteins colocalize with telomeres in >95% of LPs but in

Original language	English
Pages (from-to)	28-37
Number of pages	10
Journal	Stem Cell Reports
Volume	1
Issue number	1
DOIs	https://doi.org/10.1016/j.stemcr.2013.04.003
Publication status	Published - 4-Jun-2013

Keywords

EPITHELIAL-CELLS
FLOW-CYTOMETRY
CANCER-CELLS
MRN COMPLEX
DNA-DAMAGE
STEM-CELLS
LENGTH
EXPRESSION
REPAIR
ASSOCIATION

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Cite this

Kannan, Nagarajan ; Huda, Nazmul ; Tu, LiRen ; Droumeva, Radina ; Aubert, Geraldine ; Chavez, Elizabeth ; Brinkman, Ryan R. ; Lansdorp, Peter ; Emerman, Joanne ; Abe, Satoshi ; Eaves, Connie ; Gilley, David. / The Luminal Progenitor Compartment of the Normal Human Mammary Gland Constitutes a Unique Site of Telomere Dysfunction. In: Stem Cell Reports. 2013 ; Vol. 1, No. 1. pp. 28-37.

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abstract = "Telomeres are essential for genomic integrity, but little is known about their regulation in the normal human mammary gland. We now demonstrate that a phenotypically defined cell population enriched in luminal progenitors (LPs) is characterized by unusually short telomeres independently of donor age. Furthermore, we find that multiple DNA damage response proteins colocalize with telomeres in >95% of LPs but in",

keywords = "EPITHELIAL-CELLS, FLOW-CYTOMETRY, CANCER-CELLS, MRN COMPLEX, DNA-DAMAGE, STEM-CELLS, LENGTH, EXPRESSION, REPAIR, ASSOCIATION",

author = "Nagarajan Kannan and Nazmul Huda and LiRen Tu and Radina Droumeva and Geraldine Aubert and Elizabeth Chavez and Brinkman, {Ryan R.} and Peter Lansdorp and Joanne Emerman and Satoshi Abe and Connie Eaves and David Gilley",

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The Luminal Progenitor Compartment of the Normal Human Mammary Gland Constitutes a Unique Site of Telomere Dysfunction. / Kannan, Nagarajan; Huda, Nazmul; Tu, LiRen; Droumeva, Radina; Aubert, Geraldine; Chavez, Elizabeth; Brinkman, Ryan R.; Lansdorp, Peter; Emerman, Joanne; Abe, Satoshi; Eaves, Connie; Gilley, David.

In: Stem Cell Reports, Vol. 1, No. 1, 04.06.2013, p. 28-37.

Research output: Contribution to journal › Article › Academic › peer-review

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