The Luminal Progenitor Compartment of the Normal Human Mammary Gland Constitutes a Unique Site of Telomere Dysfunction

Nagarajan Kannan, Nazmul Huda, LiRen Tu, Radina Droumeva, Geraldine Aubert, Elizabeth Chavez, Ryan R. Brinkman, Peter Lansdorp, Joanne Emerman, Satoshi Abe, Connie Eaves*, David Gilley

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Telomeres are essential for genomic integrity, but little is known about their regulation in the normal human mammary gland. We now demonstrate that a phenotypically defined cell population enriched in luminal progenitors (LPs) is characterized by unusually short telomeres independently of donor age. Furthermore, we find that multiple DNA damage response proteins colocalize with telomeres in >95% of LPs but in

Original languageEnglish
Pages (from-to)28-37
Number of pages10
JournalStem Cell Reports
Volume1
Issue number1
DOIs
Publication statusPublished - 4-Jun-2013

Keywords

  • EPITHELIAL-CELLS
  • FLOW-CYTOMETRY
  • CANCER-CELLS
  • MRN COMPLEX
  • DNA-DAMAGE
  • STEM-CELLS
  • LENGTH
  • EXPRESSION
  • REPAIR
  • ASSOCIATION

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