The metabolic syndrome in long-term cancer survivors, an important target for secondary preventive measures

J Nuver, AJ Smit, A Postma, DT Sleijfer, JA Gietema*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

87 Citations (Scopus)

Abstract

With increasing numbers of cancer survivors, attention has been drawn to long-term complications of curative cancer treatment, including a range of metabolic disorders. These metabolic disorders often resemble the components of the so-called metabolic syndrome, or syndrome X, which is an important risk factor for the development of cardiovascular disease. The mechanisms behind the development of metabolic disorders in cancer survivors have not been fully elucidated. However, association studies in the general population have demonstrated correlations between the components of the metabolic syndrome on the one hand and hormonal deficiencies, hypomagnesaemia, and endothelial dysfunction on the other. These latter disorders are regularly reported following curative cancer treatment and could, therefore, be important aetiologic factors in the development of the metabolic syndrome in cancer survivors. This review discusses data on the associations between the metabolic syndrome and treatment-related complications in cancer survivors and possibilities for preventive measures. (C) 2002 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)195-214
Number of pages20
JournalCANCER TREATMENT REVIEWS
Volume28
Issue number4
DOIs
Publication statusPublished - Aug-2002

Keywords

  • long-term cancer survivors
  • metabolic syndrome
  • syndrome X
  • hormones
  • magnesium
  • endothelial dysfunction
  • BONE-MARROW TRANSPLANTATION
  • GROWTH-HORMONE DEFICIENCY
  • TOTAL-BODY IRRADIATION
  • ACUTE LYMPHOBLASTIC-LEUKEMIA
  • INSULIN-RESISTANCE SYNDROME
  • IMPAIRED GLUCOSE-TOLERANCE
  • DENSITY-LIPOPROTEIN CHOLESTEROL
  • CARDIOVASCULAR RISK-FACTORS
  • CORONARY HEART-DISEASE
  • GERM-CELL TUMORS

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