The MHC locus and genetic susceptibility to autoimmune and infectious diseases

Vasiliki Matzaraki, Vinod Kumar, Cisca Wijmenga*, Alexandra Zhernakova

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

142 Citations (Scopus)
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Abstract

In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also known as the human leukocyte antigen (HLA), have been reported as major risk factors for complex diseases. Recent advances, including large genetic screens, imputation, and analyses of non-additive and epistatic effects, have contributed to a better understanding of the shared and specific roles of MHC variants in different diseases. We review these advances and discuss the relationships between MHC variants involved in autoimmune and infectious diseases. Further work in this area will help to distinguish between alternative hypotheses for the role of pathogens in autoimmune disease development.

Original languageEnglish
Article number76
Number of pages21
JournalGenome Biology
Volume18
Issue number76
DOIs
Publication statusPublished - 27-Apr-2017

Keywords

  • GENOME-WIDE ASSOCIATION
  • CHRONIC HEPATITIS-B
  • MAJOR HISTOCOMPATIBILITY COMPLEX
  • SYSTEMIC-LUPUS-ERYTHEMATOSUS
  • C VIRUS-INFECTION
  • IMMUNOGLOBULIN-LIKE RECEPTORS
  • INFLAMMATORY-BOWEL-DISEASE
  • AMINO-ACID POSITIONS
  • HL-A ANTIGENS
  • RHEUMATOID-ARTHRITIS

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