The nature and identification of quantitative trait loci: a community's view

O Abiola; JM Angel; P Avner; AA Bachmanov; JK Belknap; B Bennett; EP Blankenhorn; DA Blizard; [No Value] Bolivar; GA Brockmann; KJ Buck; JF Bureau; WL Casley; EJ Chesler; JM Cheverud; GA Churchill; M Cook; JC Crabbe; WE Crusio; A Darvasi; G de Haan; P Demant; RW Doerge; RW Elliott; CR Farber; L Flaherty; J Flint; H Gershenfeld; JPGJ Gu; WK Gu; H Himmelbauer; R Hitzemann; HC Hsu; K Hunter; FA Iraqi; RC Jansen; TE Johnson; BC Jones; G Kempermann; F Lammert; L Lu; KF Manly; DB Matthews; JF Medrano; M Mehrabian; G Mittleman; BA Mock; JS Mogil; [No Value] Montagutelli; G Morahan; Complex Trait Consortium

doi:10.1038/nrg1206

The nature and identification of quantitative trait loci: a community's view

O Abiola
, JM Angel
, P Avner
, AA Bachmanov
, JK Belknap
, B Bennett
, EP Blankenhorn
, DA Blizard
, [No Value] Bolivar
, GA Brockmann
, KJ Buck
, JF Bureau
, WL Casley
, EJ Chesler
, JM Cheverud
, GA Churchill
, M Cook
, JC Crabbe
, WE Crusio
, A Darvasi

G de Haan, P Demant, RW Doerge, RW Elliott, CR Farber, L Flaherty, J Flint, H Gershenfeld, JPGJ Gu, WK Gu, H Himmelbauer, R Hitzemann, HC Hsu, K Hunter, FA Iraqi, RC Jansen, TE Johnson, BC Jones, G Kempermann, F Lammert, L Lu, KF Manly, DB Matthews, JF Medrano, M Mehrabian, G Mittleman, BA Mock, JS Mogil, [No Value] Montagutelli, G Morahan, Complex Trait Consortium

Research output: Contribution to journal › Review article › peer-review

393 Citations (Scopus)

Abstract

This white paper by eighty members of the Complex Trait Consortium presents a community’s view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?

Original language	English
Pages (from-to)	911-916
Number of pages	6
Journal	Nature Reviews Genetics
Volume	4
Issue number	11
DOIs	https://doi.org/10.1038/nrg1206
Publication status	Published - Nov-2003

Keywords

GENETIC DISSECTION
PREFERENCE DRINKING
COMPLEX TRAITS
MICE
ALCOHOL
STRAINS
LINKAGE
LINES
QTL
POPULATION

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Abiola, O., Angel, JM., Avner, P., Bachmanov, AA., Belknap, JK., Bennett, B., Blankenhorn, EP., Blizard, DA., Bolivar, N. V., Brockmann, GA., Buck, KJ., Bureau, JF., Casley, WL., Chesler, EJ., Cheverud, JM., Churchill, GA., Cook, M., Crabbe, JC., Crusio, WE., ... Complex Trait Consortium (2003). The nature and identification of quantitative trait loci: a community's view. Nature Reviews Genetics, 4(11), 911-916. https://doi.org/10.1038/nrg1206

@article{3dee453dbe084b4eacbba9ff5329fb3c,

title = "The nature and identification of quantitative trait loci: a community's view",

abstract = "This white paper by eighty members of the Complex Trait Consortium presents a community{\textquoteright}s view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?",

keywords = "GENETIC DISSECTION, PREFERENCE DRINKING, COMPLEX TRAITS, MICE, ALCOHOL, STRAINS, LINKAGE, LINES, QTL, POPULATION",

author = "O Abiola and JM Angel and P Avner and AA Bachmanov and JK Belknap and B Bennett and EP Blankenhorn and DA Blizard and Bolivar, \{[No Value]\} and GA Brockmann and KJ Buck and JF Bureau and WL Casley and EJ Chesler and JM Cheverud and GA Churchill and M Cook and JC Crabbe and WE Crusio and A Darvasi and \{de Haan\}, G and P Demant and RW Doerge and RW Elliott and CR Farber and L Flaherty and J Flint and H Gershenfeld and JPGJ Gu and WK Gu and H Himmelbauer and R Hitzemann and HC Hsu and K Hunter and FA Iraqi and RC Jansen and TE Johnson and BC Jones and G Kempermann and F Lammert and L Lu and KF Manly and DB Matthews and JF Medrano and M Mehrabian and G Mittleman and BA Mock and JS Mogil and Montagutelli, \{[No Value]\} and G Morahan and \{Complex Trait Consortium\}",

note = "Relation: http://www.rug.nl/ Rights: http://rs.ub.rug.nl/keur/",

year = "2003",

month = nov,

doi = "10.1038/nrg1206",

language = "English",

volume = "4",

pages = "911--916",

journal = "Nature Reviews Genetics",

issn = "1471-0056",

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Abiola, O, Angel, JM, Avner, P, Bachmanov, AA, Belknap, JK, Bennett, B, Blankenhorn, EP, Blizard, DA, Bolivar, NV, Brockmann, GA, Buck, KJ, Bureau, JF, Casley, WL, Chesler, EJ, Cheverud, JM, Churchill, GA, Cook, M, Crabbe, JC, Crusio, WE, Darvasi, A, de Haan, G, Demant, P, Doerge, RW, Elliott, RW, Farber, CR, Flaherty, L, Flint, J, Gershenfeld, H, Gu, JPGJ, Gu, WK, Himmelbauer, H, Hitzemann, R, Hsu, HC, Hunter, K, Iraqi, FA, Jansen, RC, Johnson, TE, Jones, BC, Kempermann, G, Lammert, F, Lu, L, Manly, KF, Matthews, DB, Medrano, JF, Mehrabian, M, Mittleman, G, Mock, BA, Mogil, JS, Montagutelli, NV, Morahan, G & Complex Trait Consortium 2003, 'The nature and identification of quantitative trait loci: a community's view', Nature Reviews Genetics, vol. 4, no. 11, pp. 911-916. https://doi.org/10.1038/nrg1206

TY - JOUR

T1 - The nature and identification of quantitative trait loci

T2 - a community's view

AU - Abiola, O

AU - Angel, JM

AU - Avner, P

AU - Bachmanov, AA

AU - Belknap, JK

AU - Bennett, B

AU - Blankenhorn, EP

AU - Blizard, DA

AU - Bolivar, [No Value]

AU - Brockmann, GA

AU - Buck, KJ

AU - Bureau, JF

AU - Casley, WL

AU - Chesler, EJ

AU - Cheverud, JM

AU - Churchill, GA

AU - Cook, M

AU - Crabbe, JC

AU - Crusio, WE

AU - Darvasi, A

AU - de Haan, G

AU - Demant, P

AU - Doerge, RW

AU - Elliott, RW

AU - Farber, CR

AU - Flaherty, L

AU - Flint, J

AU - Gershenfeld, H

AU - Gu, JPGJ

AU - Gu, WK

AU - Himmelbauer, H

AU - Hitzemann, R

AU - Hsu, HC

AU - Hunter, K

AU - Iraqi, FA

AU - Jansen, RC

AU - Johnson, TE

AU - Jones, BC

AU - Kempermann, G

AU - Lammert, F

AU - Lu, L

AU - Manly, KF

AU - Matthews, DB

AU - Medrano, JF

AU - Mehrabian, M

AU - Mittleman, G

AU - Mock, BA

AU - Mogil, JS

AU - Montagutelli, [No Value]

AU - Morahan, G

AU - Complex Trait Consortium

N1 - Relation: http://www.rug.nl/ Rights: http://rs.ub.rug.nl/keur/

PY - 2003/11

Y1 - 2003/11

N2 - This white paper by eighty members of the Complex Trait Consortium presents a community’s view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?

AB - This white paper by eighty members of the Complex Trait Consortium presents a community’s view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?

KW - GENETIC DISSECTION

KW - PREFERENCE DRINKING

KW - COMPLEX TRAITS

KW - MICE

KW - ALCOHOL

KW - STRAINS

KW - LINKAGE

KW - LINES

KW - QTL

KW - POPULATION

U2 - 10.1038/nrg1206

DO - 10.1038/nrg1206

M3 - Review article

SN - 1471-0056

VL - 4

SP - 911

EP - 916

JO - Nature Reviews Genetics

JF - Nature Reviews Genetics

IS - 11

ER -

The nature and identification of quantitative trait loci: a community's view

Abstract

Keywords

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