The neurobiology of circadian rhythms

Eddy A. van der Zee*, Gretha J. Boersma, Roelof A. Hut

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

18 Citations (Scopus)
937 Downloads (Pure)

Abstract

Purpose of review

There is growing awareness of the importance of circadian rhythmicity in various research fields. Exciting developments are ongoing in the field of circadian neurobiology linked to sleep, food intake, and memory. With the current knowledge of critical clock genes' (genes found to be involved in the generation of circadian rhythms) and novel techniques for imaging cyclic events in brain and peripheral tissue, this field of research is rapidly expanding. We reviewed only some of the highlights of the past year, and placed these findings into a mutual circadian perspective. Recent findings

Recent findings

on the organization of the circadian clock systems are addressed, ranging from the retina to the suprachiasmatic nucleus and peripheral organs. Novel developments in sleep, food intake, and memory research linked to circadian aspects are discussed.

Summary

The neurobiology of circadian rhythms is pivotal to the orchestration of the temporal organization of an individual's physiology and behavior. Endogenous circadian timing systems underlie coupling and uncoupling mechanisms of many neuronal and physiological processes, the latter possibly inducing health risks to the organism. The integration of sleep, food intake and memory in a circadian setting has clear potential as a systems neurobiology line of research.

Original languageEnglish
Pages (from-to)534-539
Number of pages6
JournalCurrent Opinion in Pulmonary Medicine
Volume15
Issue number6
DOIs
Publication statusPublished - Nov-2009

Keywords

  • energy homeostasis
  • memory
  • sleep
  • suprachiasmatic nucleus
  • CLOCK GENE-EXPRESSION
  • SUPRACHIASMATIC NUCLEUS
  • HIPPOCAMPAL NEUROGENESIS
  • FOOD ANTICIPATION
  • SLEEP HOMEOSTASIS
  • DROSOPHILA SLEEP
  • HUMAN RETINA
  • MUTANT MICE
  • MELANOPSIN
  • MEMORY

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