TY - JOUR
T1 - The NeuroIMAGE study
T2 - a prospective phenotypic, cognitive, genetic and MRI study in children with attention-deficit/hyperactivity disorder. Design and descriptives
AU - von Rhein, Daniel
AU - Mennes, Maarten
AU - van Ewijk, Hanneke
AU - Groenman, Annabeth P.
AU - Zwiers, Marcel P.
AU - Oosterlaan, Jaap
AU - Heslenfeld, Dirk
AU - Franke, Barbara
AU - Hoekstra, Pieter J.
AU - Faraone, Stephen V.
AU - Hartman, Catharina
AU - Buitelaar, Jan
PY - 2015/3
Y1 - 2015/3
N2 - Attention-deficit/hyperactivity disorder (ADHD) is a persistent neuropsychiatric disorder which is associated with impairments on a variety of cognitive measures and abnormalities in structural and functional brain measures. Genetic factors are thought to play an important role in the etiology of ADHD. The NeuroIMAGE study is a follow-up of the Dutch part of the International Multicenter ADHD Genetics (IMAGE) project. It is a multi-site prospective cohort study designed to investigate the course of ADHD, its genetic and environmental determinants, its cognitive and neurobiological underpinnings, and its consequences in adolescence and adulthood. From the original 365 ADHD families and 148 control (CON) IMAGE families, consisting of 506 participants with an ADHD diagnosis, 350 unaffected siblings, and 283 healthy controls, 79 % participated in the NeuroIMAGE follow-up study. Combined with newly recruited participants the NeuroIMAGE study comprehends an assessment of 1,069 children (751 from ADHD families; 318 from CON families) and 848 parents (582 from ADHD families; 266 from CON families). For most families, data for more than one child (82 %) and both parents (82 %) were available. Collected data include a diagnostic interview, behavioural questionnaires, cognitive measures, structural and functional neuroimaging, and genome-wide genetic information. The NeuroIMAGE dataset allows examining the course of ADHD over adolescence into young adulthood, identifying phenotypic, cognitive, and neural mechanisms associated with the persistence versus remission of ADHD, and studying their genetic and environmental underpinnings. The inclusion of siblings of ADHD probands and controls allows modelling of shared familial influences on the ADHD phenotype.
AB - Attention-deficit/hyperactivity disorder (ADHD) is a persistent neuropsychiatric disorder which is associated with impairments on a variety of cognitive measures and abnormalities in structural and functional brain measures. Genetic factors are thought to play an important role in the etiology of ADHD. The NeuroIMAGE study is a follow-up of the Dutch part of the International Multicenter ADHD Genetics (IMAGE) project. It is a multi-site prospective cohort study designed to investigate the course of ADHD, its genetic and environmental determinants, its cognitive and neurobiological underpinnings, and its consequences in adolescence and adulthood. From the original 365 ADHD families and 148 control (CON) IMAGE families, consisting of 506 participants with an ADHD diagnosis, 350 unaffected siblings, and 283 healthy controls, 79 % participated in the NeuroIMAGE follow-up study. Combined with newly recruited participants the NeuroIMAGE study comprehends an assessment of 1,069 children (751 from ADHD families; 318 from CON families) and 848 parents (582 from ADHD families; 266 from CON families). For most families, data for more than one child (82 %) and both parents (82 %) were available. Collected data include a diagnostic interview, behavioural questionnaires, cognitive measures, structural and functional neuroimaging, and genome-wide genetic information. The NeuroIMAGE dataset allows examining the course of ADHD over adolescence into young adulthood, identifying phenotypic, cognitive, and neural mechanisms associated with the persistence versus remission of ADHD, and studying their genetic and environmental underpinnings. The inclusion of siblings of ADHD probands and controls allows modelling of shared familial influences on the ADHD phenotype.
KW - Attention-deficit/hyperactivity disorder
KW - Cognition
KW - Imaging
KW - Genetics
KW - Development
KW - Familiality
KW - DEFICIT HYPERACTIVITY DISORDER
KW - GENOME-WIDE ASSOCIATION
KW - FUNCTIONAL CONNECTIVITY MRI
KW - LARGE MULTICENTER ADHD
KW - SUBSTANCE USE
KW - REWARD ANTICIPATION
KW - DIAGNOSTIC-APPROACH
KW - CRITERION VALIDITY
KW - SCREENING SCALES
KW - CANDIDATE GENE
U2 - 10.1007/s00787-014-0573-4
DO - 10.1007/s00787-014-0573-4
M3 - Article
SN - 1018-8827
VL - 24
SP - 265
EP - 281
JO - European Child & Adolescent Psychiatry
JF - European Child & Adolescent Psychiatry
IS - 3
ER -