The obsessive compulsive spectrum in schizophrenia, a meta-analysis and meta-regression exploring prevalence rates

Marije Swets; Jack Dekker; Katelijne van Emmerik-van Oortmerssen; Geert E. Smid; Filip Smit; Lieuwe de Haan; Robert A. Schoevers

doi:10.1016/j.schres.2013.10.033

The obsessive compulsive spectrum in schizophrenia, a meta-analysis and meta-regression exploring prevalence rates

Marije Swets^*, Jack Dekker, Katelijne van Emmerik-van Oortmerssen, Geert E. Smid, Filip Smit, Lieuwe de Haan, Robert A. Schoevers

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

146 Citations (Scopus)

Abstract

Aims: The aims of this study were to conduct a meta-analysis and meta-regression to estimate the prevalence rates for obsessive compulsive symptoms (OCS) and obsessive compulsive disorder (OCD) in schizophrenia, and to investigate what influences these prevalence rates.

Method: Studies were identified via an online OVID database search, including PsychInfo, Embase and Medline until December 2009.

Results: Forty-three studies summarizing outcomes for 3978 subjects met inclusion criteria. The mean OCD prevalence is 12.3%, slightly increasing to 13.6% after adjustment in meta-regression. The prevalence rate of OCS, defined as any obsession or compulsion is 30.7% (30.3% adjusted). Higher severity of OCS, DIGS assessment, and Sub-Saharan African origin of study are associated with a lower OCS/OCD prevalence rate, use of DSM-IV edition, Y-BOCS assessment and longer schizophrenia history are associated with a higher prevalence rate.

Conclusion: The prevalence of OCS and OCD in schizophrenia is substantial, specifically in more chronic patient populations and is influenced by the method of assessment. (C) 2013 Elsevier B. V. All rights reserved.

Original language	English
Pages (from-to)	458-468
Number of pages	11
Journal	Schizophrenia Research
Volume	152
Issue number	2-3
DOIs	https://doi.org/10.1016/j.schres.2013.10.033
Publication status	Published - Feb-2014

Keywords

Schizophrenia
Psychotic disorder
Obsessive compulsive disorder
Meta-analysis
RECENT-ONSET SCHIZOPHRENIA
COMORBIDITY SURVEY REPLICATION
QUALITY-OF-LIFE
SCHIZOAFFECTIVE DISORDER
PSYCHOTIC DISORDERS
ANXIETY DISORDERS
PSYCHIATRIC COMORBIDITY
COGNITIVE FUNCTION
CLINICAL-FEATURES
NEGATIVE SYMPTOMS

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title = "The obsessive compulsive spectrum in schizophrenia, a meta-analysis and meta-regression exploring prevalence rates",

abstract = "Aims: The aims of this study were to conduct a meta-analysis and meta-regression to estimate the prevalence rates for obsessive compulsive symptoms (OCS) and obsessive compulsive disorder (OCD) in schizophrenia, and to investigate what influences these prevalence rates.Method: Studies were identified via an online OVID database search, including PsychInfo, Embase and Medline until December 2009.Results: Forty-three studies summarizing outcomes for 3978 subjects met inclusion criteria. The mean OCD prevalence is 12.3%, slightly increasing to 13.6% after adjustment in meta-regression. The prevalence rate of OCS, defined as any obsession or compulsion is 30.7% (30.3% adjusted). Higher severity of OCS, DIGS assessment, and Sub-Saharan African origin of study are associated with a lower OCS/OCD prevalence rate, use of DSM-IV edition, Y-BOCS assessment and longer schizophrenia history are associated with a higher prevalence rate.Conclusion: The prevalence of OCS and OCD in schizophrenia is substantial, specifically in more chronic patient populations and is influenced by the method of assessment. (C) 2013 Elsevier B. V. All rights reserved.",

keywords = "Schizophrenia, Psychotic disorder, Obsessive compulsive disorder, Meta-analysis, RECENT-ONSET SCHIZOPHRENIA, COMORBIDITY SURVEY REPLICATION, QUALITY-OF-LIFE, SCHIZOAFFECTIVE DISORDER, PSYCHOTIC DISORDERS, ANXIETY DISORDERS, PSYCHIATRIC COMORBIDITY, COGNITIVE FUNCTION, CLINICAL-FEATURES, NEGATIVE SYMPTOMS",

author = "Marije Swets and Jack Dekker and {van Emmerik-van Oortmerssen}, Katelijne and Smid, {Geert E.} and Filip Smit and {de Haan}, Lieuwe and Schoevers, {Robert A.}",

year = "2014",

month = feb,

doi = "10.1016/j.schres.2013.10.033",

language = "English",

volume = "152",

pages = "458--468",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "ELSEVIER SCIENCE BV",

number = "2-3",

}

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T1 - The obsessive compulsive spectrum in schizophrenia, a meta-analysis and meta-regression exploring prevalence rates

AU - Swets, Marije

AU - Dekker, Jack

AU - van Emmerik-van Oortmerssen, Katelijne

AU - Smid, Geert E.

AU - Smit, Filip

AU - de Haan, Lieuwe

AU - Schoevers, Robert A.

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N2 - Aims: The aims of this study were to conduct a meta-analysis and meta-regression to estimate the prevalence rates for obsessive compulsive symptoms (OCS) and obsessive compulsive disorder (OCD) in schizophrenia, and to investigate what influences these prevalence rates.Method: Studies were identified via an online OVID database search, including PsychInfo, Embase and Medline until December 2009.Results: Forty-three studies summarizing outcomes for 3978 subjects met inclusion criteria. The mean OCD prevalence is 12.3%, slightly increasing to 13.6% after adjustment in meta-regression. The prevalence rate of OCS, defined as any obsession or compulsion is 30.7% (30.3% adjusted). Higher severity of OCS, DIGS assessment, and Sub-Saharan African origin of study are associated with a lower OCS/OCD prevalence rate, use of DSM-IV edition, Y-BOCS assessment and longer schizophrenia history are associated with a higher prevalence rate.Conclusion: The prevalence of OCS and OCD in schizophrenia is substantial, specifically in more chronic patient populations and is influenced by the method of assessment. (C) 2013 Elsevier B. V. All rights reserved.

AB - Aims: The aims of this study were to conduct a meta-analysis and meta-regression to estimate the prevalence rates for obsessive compulsive symptoms (OCS) and obsessive compulsive disorder (OCD) in schizophrenia, and to investigate what influences these prevalence rates.Method: Studies were identified via an online OVID database search, including PsychInfo, Embase and Medline until December 2009.Results: Forty-three studies summarizing outcomes for 3978 subjects met inclusion criteria. The mean OCD prevalence is 12.3%, slightly increasing to 13.6% after adjustment in meta-regression. The prevalence rate of OCS, defined as any obsession or compulsion is 30.7% (30.3% adjusted). Higher severity of OCS, DIGS assessment, and Sub-Saharan African origin of study are associated with a lower OCS/OCD prevalence rate, use of DSM-IV edition, Y-BOCS assessment and longer schizophrenia history are associated with a higher prevalence rate.Conclusion: The prevalence of OCS and OCD in schizophrenia is substantial, specifically in more chronic patient populations and is influenced by the method of assessment. (C) 2013 Elsevier B. V. All rights reserved.

KW - Schizophrenia

KW - Psychotic disorder

KW - Obsessive compulsive disorder

KW - Meta-analysis

KW - RECENT-ONSET SCHIZOPHRENIA

KW - COMORBIDITY SURVEY REPLICATION

KW - QUALITY-OF-LIFE

KW - SCHIZOAFFECTIVE DISORDER

KW - PSYCHOTIC DISORDERS

KW - ANXIETY DISORDERS

KW - PSYCHIATRIC COMORBIDITY

KW - COGNITIVE FUNCTION

KW - CLINICAL-FEATURES

KW - NEGATIVE SYMPTOMS

U2 - 10.1016/j.schres.2013.10.033

DO - 10.1016/j.schres.2013.10.033

M3 - Review article

SN - 0920-9964

VL - 152

SP - 458

EP - 468

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 2-3

ER -

The obsessive compulsive spectrum in schizophrenia, a meta-analysis and meta-regression exploring prevalence rates

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Keywords

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