The origin of fibroblasts and mechanism of cardiac fibrosis.

Guido Krenning, Elisabeth Zeisberg, Raghu Kalluri

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Abstract

Fibroblasts are at the heart of cardiac function and are the principal determinants of cardiac fibrosis. Nevertheless, cardiac fibroblasts remain poorly characterized in molecular terms. Evidence is evolving that the cardiac fibroblast is a highly heterogenic cell population, and that such heterogeneity is caused by the distinct origins of fibroblasts in the heart. Cardiac fibroblasts can derive either from resident fibroblasts, from endothelial cells via an endothelial-mesenchynmal transition or from bone marrow-derived circulating progenitor cells, monocytes and fibrocytes. Here, we review the function and origin of fibroblasts in cardiac fibrosis.
Original languageEnglish
Pages (from-to)631-637
Number of pages6
JournalJournal of Cellular Physiology
Volume225
Issue number3
Early online date15-Jul-2010
DOIs
Publication statusPublished - Nov-2010

Keywords

  • fibroblast
  • endothelial-mesenchymal transition
  • CARDIAC FIBROSIS
  • ENDOTHELIAL CELLS

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