THE P-31-NMR SPECTROSCOPIC DETERMINATION OF THE ENANTIOMERIC EXCESS OF UNPROTECTED AMINO-ACIDS

R HULST, NK DEVRIES, BL FERINGA

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Abstract

No separation is needed! The enantiomeric excess of unprotected amino acids can be determined very reliable by P-31 NMR spectroscopy after derivatization as phosphonic amides 1. This rapid and simple analytical procedure, suitable for aqueous solutions. is also applicable for amino acid derivatives, chiral amines, and alcohols.

Original languageEnglish
Pages (from-to)1092-1093
Number of pages2
JournalAngewandte Chemie-International Edition in English
Volume31
Issue number8
Publication statusPublished - Aug-1992

Keywords

  • GAS-CHROMATOGRAPHIC SEPARATION
  • CHIRAL AUXILIARY COMPOUNDS
  • NMR METHOD
  • DERIVATIVES
  • ALCOHOLS

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