The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution

Deanne M. Taylor; Bruce J. Aronow; Kai Tan; Kathrin Bernt; Nathan Salomonis; Casey S. Greene; Alina Frolova; Sarah E. Henrickson; Andrew Wells; Liming Pei; Jyoti K. Jaiswal; Jeffrey Whitsett; Kathryn E. Hamilton; Sonya A. MacParland; Judith Kelsen; Robert O. Heuckeroth; S. Steven Potter; Laura A. Vella; Natalie A. Terry; Louis R. Ghanem; Benjamin C. Kennedy; Ingo Helbig; Kathleen E. Sullivan; Leslie Castelo-Soccio; Arnold Kreigstein; Florian Herse; Martijn C. Nawijn; Gerard H. Koppelman; Melissa Haendel; Nomi L. Harris; Jo Lynne Rokita; Yuanchao Zhang; Aviv Regev; Orit Rozenblatt-Rosen; Jennifer E. Rood; Timothy L. Tickle; Roser Vento-Tormo; Saif Alimohamed; Monkol Lek; Jessica C. Mar; Kathleen M. Loomes; David M. Barrett; Prech Uapinyoying; Alan H. Beggs; Pankaj B. Agrawal; Yi-Wen Chen; Amanda B. Muir; Lana X. Garmire; Scott B. Snapper; Javad Nazarian; Steven H. Seeholzer; Hossein Fazelinia; Larry N. Singh; Robert B. Faryabi; Pichai Raman; Noor Dawany; Hongbo Michael Xie; Batsal Devkota; Sharon J. Diskin; Stewart A. Anderson; Eric F. Rappaport; William Peranteau; Kathryn A. Wikenheiser-Brokamp; Sarah Teichmann; Douglas Wallace; Tao Peng; Yang-yang Ding; Man S. Kim; Yi Xing; Sek Won Kong; Carsten G. Bonnemann; Kenneth D. Mandl; Peter S. White

doi:10.1016/j.devcel.2019.03.001

The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution

Deanne M. Taylor, Bruce J. Aronow, Kai Tan, Kathrin Bernt, Nathan Salomonis, Casey S. Greene, Alina Frolova, Sarah E. Henrickson, Andrew Wells, Liming Pei, Jyoti K. Jaiswal, Jeffrey Whitsett, Kathryn E. Hamilton, Sonya A. MacParland, Judith Kelsen, Robert O. Heuckeroth, S. Steven Potter, Laura A. Vella, Natalie A. Terry, Louis R. GhanemBenjamin C. Kennedy, Ingo Helbig, Kathleen E. Sullivan, Leslie Castelo-Soccio, Arnold Kreigstein, Florian Herse, Martijn C. Nawijn, Gerard H. Koppelman, Melissa Haendel, Nomi L. Harris, Jo Lynne Rokita, Yuanchao Zhang, Aviv Regev, Orit Rozenblatt-Rosen, Jennifer E. Rood, Timothy L. Tickle, Roser Vento-Tormo, Saif Alimohamed, Monkol Lek, Jessica C. Mar, Kathleen M. Loomes, David M. Barrett, Prech Uapinyoying, Alan H. Beggs, Pankaj B. Agrawal, Yi-Wen Chen, Amanda B. Muir, Lana X. Garmire, Scott B. Snapper, Javad Nazarian, Steven H. Seeholzer, Hossein Fazelinia, Larry N. Singh, Robert B. Faryabi, Pichai Raman, Noor Dawany, Hongbo Michael Xie, Batsal Devkota, Sharon J. Diskin, Stewart A. Anderson, Eric F. Rappaport, William Peranteau, Kathryn A. Wikenheiser-Brokamp, Sarah Teichmann, Douglas Wallace, Tao Peng, Yang-yang Ding, Man S. Kim, Yi Xing, Sek Won Kong, Carsten G. Bonnemann, Kenneth D. Mandl, Peter S. White

Groningen Research Institute for Asthma and COPD (GRIAC)

Research output: Contribution to journal › Review article › peer-review

22 Citations (Scopus)

432 Downloads (Pure)

Abstract

Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan.

Original language	English
Pages (from-to)	10-29
Number of pages	20
Journal	Developmental Cell
Volume	49
Issue number	1
DOIs	https://doi.org/10.1016/j.devcel.2019.03.001
Publication status	Published - 8-Apr-2019

Keywords

INFLAMMATORY-BOWEL-DISEASE
ACUTE LYMPHOBLASTIC-LEUKEMIA
CHRONIC KIDNEY-DISEASE
BILIARY ATRESIA
SATELLITE CELLS
GENE-EXPRESSION
HEART-DISEASE
RNA-SEQ
SOMATIC MUTATIONS
CHILDRENS HEALTH

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Taylor, D. M., Aronow, B. J., Tan, K., Bernt, K., Salomonis, N., Greene, C. S., Frolova, A., Henrickson, S. E., Wells, A., Pei, L., Jaiswal, J. K., Whitsett, J., Hamilton, K. E., MacParland, S. A., Kelsen, J., Heuckeroth, R. O., Potter, S. S., Vella, L. A., Terry, N. A., ... White, P. S. (2019). The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution. Developmental Cell, 49(1), 10-29. https://doi.org/10.1016/j.devcel.2019.03.001

Taylor, Deanne M. ; Aronow, Bruce J. ; Tan, Kai ; Bernt, Kathrin ; Salomonis, Nathan ; Greene, Casey S. ; Frolova, Alina ; Henrickson, Sarah E. ; Wells, Andrew ; Pei, Liming ; Jaiswal, Jyoti K. ; Whitsett, Jeffrey ; Hamilton, Kathryn E. ; MacParland, Sonya A. ; Kelsen, Judith ; Heuckeroth, Robert O. ; Potter, S. Steven ; Vella, Laura A. ; Terry, Natalie A. ; Ghanem, Louis R. ; Kennedy, Benjamin C. ; Helbig, Ingo ; Sullivan, Kathleen E. ; Castelo-Soccio, Leslie ; Kreigstein, Arnold ; Herse, Florian ; Nawijn, Martijn C. ; Koppelman, Gerard H. ; Haendel, Melissa ; Harris, Nomi L. ; Rokita, Jo Lynne ; Zhang, Yuanchao ; Regev, Aviv ; Rozenblatt-Rosen, Orit ; Rood, Jennifer E. ; Tickle, Timothy L. ; Vento-Tormo, Roser ; Alimohamed, Saif ; Lek, Monkol ; Mar, Jessica C. ; Loomes, Kathleen M. ; Barrett, David M. ; Uapinyoying, Prech ; Beggs, Alan H. ; Agrawal, Pankaj B. ; Chen, Yi-Wen ; Muir, Amanda B. ; Garmire, Lana X. ; Snapper, Scott B. ; Nazarian, Javad ; Seeholzer, Steven H. ; Fazelinia, Hossein ; Singh, Larry N. ; Faryabi, Robert B. ; Raman, Pichai ; Dawany, Noor ; Xie, Hongbo Michael ; Devkota, Batsal ; Diskin, Sharon J. ; Anderson, Stewart A. ; Rappaport, Eric F. ; Peranteau, William ; Wikenheiser-Brokamp, Kathryn A. ; Teichmann, Sarah ; Wallace, Douglas ; Peng, Tao ; Ding, Yang-yang ; Kim, Man S. ; Xing, Yi ; Kong, Sek Won ; Bonnemann, Carsten G. ; Mandl, Kenneth D. ; White, Peter S. / The Pediatric Cell Atlas : Defining the Growth Phase of Human Development at Single-Cell Resolution. In: Developmental Cell. 2019 ; Vol. 49, No. 1. pp. 10-29.

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abstract = "Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan.",

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author = "Taylor, {Deanne M.} and Aronow, {Bruce J.} and Kai Tan and Kathrin Bernt and Nathan Salomonis and Greene, {Casey S.} and Alina Frolova and Henrickson, {Sarah E.} and Andrew Wells and Liming Pei and Jaiswal, {Jyoti K.} and Jeffrey Whitsett and Hamilton, {Kathryn E.} and MacParland, {Sonya A.} and Judith Kelsen and Heuckeroth, {Robert O.} and Potter, {S. Steven} and Vella, {Laura A.} and Terry, {Natalie A.} and Ghanem, {Louis R.} and Kennedy, {Benjamin C.} and Ingo Helbig and Sullivan, {Kathleen E.} and Leslie Castelo-Soccio and Arnold Kreigstein and Florian Herse and Nawijn, {Martijn C.} and Koppelman, {Gerard H.} and Melissa Haendel and Harris, {Nomi L.} and Rokita, {Jo Lynne} and Yuanchao Zhang and Aviv Regev and Orit Rozenblatt-Rosen and Rood, {Jennifer E.} and Tickle, {Timothy L.} and Roser Vento-Tormo and Saif Alimohamed and Monkol Lek and Mar, {Jessica C.} and Loomes, {Kathleen M.} and Barrett, {David M.} and Prech Uapinyoying and Beggs, {Alan H.} and Agrawal, {Pankaj B.} and Yi-Wen Chen and Muir, {Amanda B.} and Garmire, {Lana X.} and Snapper, {Scott B.} and Javad Nazarian and Seeholzer, {Steven H.} and Hossein Fazelinia and Singh, {Larry N.} and Faryabi, {Robert B.} and Pichai Raman and Noor Dawany and Xie, {Hongbo Michael} and Batsal Devkota and Diskin, {Sharon J.} and Anderson, {Stewart A.} and Rappaport, {Eric F.} and William Peranteau and Wikenheiser-Brokamp, {Kathryn A.} and Sarah Teichmann and Douglas Wallace and Tao Peng and Yang-yang Ding and Kim, {Man S.} and Yi Xing and Kong, {Sek Won} and Bonnemann, {Carsten G.} and Mandl, {Kenneth D.} and White, {Peter S.}",

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doi = "10.1016/j.devcel.2019.03.001",

language = "English",

volume = "49",

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journal = "Developmental Cell",

issn = "1534-5807",

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Taylor, DM, Aronow, BJ, Tan, K, Bernt, K, Salomonis, N, Greene, CS, Frolova, A, Henrickson, SE, Wells, A, Pei, L, Jaiswal, JK, Whitsett, J, Hamilton, KE, MacParland, SA, Kelsen, J, Heuckeroth, RO, Potter, SS, Vella, LA, Terry, NA, Ghanem, LR, Kennedy, BC, Helbig, I, Sullivan, KE, Castelo-Soccio, L, Kreigstein, A, Herse, F, Nawijn, MC , Koppelman, GH, Haendel, M, Harris, NL, Rokita, JL, Zhang, Y, Regev, A, Rozenblatt-Rosen, O, Rood, JE, Tickle, TL, Vento-Tormo, R, Alimohamed, S, Lek, M, Mar, JC, Loomes, KM, Barrett, DM, Uapinyoying, P, Beggs, AH, Agrawal, PB, Chen, Y-W, Muir, AB, Garmire, LX, Snapper, SB, Nazarian, J, Seeholzer, SH, Fazelinia, H, Singh, LN, Faryabi, RB, Raman, P, Dawany, N, Xie, HM, Devkota, B, Diskin, SJ, Anderson, SA, Rappaport, EF, Peranteau, W, Wikenheiser-Brokamp, KA, Teichmann, S, Wallace, D, Peng, T, Ding, Y, Kim, MS, Xing, Y, Kong, SW, Bonnemann, CG, Mandl, KD & White, PS 2019, 'The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution', Developmental Cell, vol. 49, no. 1, pp. 10-29. https://doi.org/10.1016/j.devcel.2019.03.001

The Pediatric Cell Atlas : Defining the Growth Phase of Human Development at Single-Cell Resolution. / Taylor, Deanne M.; Aronow, Bruce J.; Tan, Kai; Bernt, Kathrin; Salomonis, Nathan; Greene, Casey S.; Frolova, Alina; Henrickson, Sarah E.; Wells, Andrew; Pei, Liming; Jaiswal, Jyoti K.; Whitsett, Jeffrey; Hamilton, Kathryn E.; MacParland, Sonya A.; Kelsen, Judith; Heuckeroth, Robert O.; Potter, S. Steven; Vella, Laura A.; Terry, Natalie A.; Ghanem, Louis R.; Kennedy, Benjamin C.; Helbig, Ingo; Sullivan, Kathleen E.; Castelo-Soccio, Leslie; Kreigstein, Arnold; Herse, Florian; Nawijn, Martijn C.; Koppelman, Gerard H.; Haendel, Melissa; Harris, Nomi L.; Rokita, Jo Lynne; Zhang, Yuanchao; Regev, Aviv; Rozenblatt-Rosen, Orit; Rood, Jennifer E.; Tickle, Timothy L.; Vento-Tormo, Roser; Alimohamed, Saif; Lek, Monkol; Mar, Jessica C.; Loomes, Kathleen M.; Barrett, David M.; Uapinyoying, Prech; Beggs, Alan H.; Agrawal, Pankaj B.; Chen, Yi-Wen; Muir, Amanda B.; Garmire, Lana X.; Snapper, Scott B.; Nazarian, Javad; Seeholzer, Steven H.; Fazelinia, Hossein; Singh, Larry N.; Faryabi, Robert B.; Raman, Pichai; Dawany, Noor; Xie, Hongbo Michael; Devkota, Batsal; Diskin, Sharon J.; Anderson, Stewart A.; Rappaport, Eric F.; Peranteau, William; Wikenheiser-Brokamp, Kathryn A.; Teichmann, Sarah; Wallace, Douglas; Peng, Tao; Ding, Yang-yang; Kim, Man S.; Xing, Yi; Kong, Sek Won; Bonnemann, Carsten G.; Mandl, Kenneth D.; White, Peter S.

In: Developmental Cell, Vol. 49, No. 1, 08.04.2019, p. 10-29.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - The Pediatric Cell Atlas

T2 - Defining the Growth Phase of Human Development at Single-Cell Resolution

AU - Taylor, Deanne M.

AU - Aronow, Bruce J.

AU - Tan, Kai

AU - Bernt, Kathrin

AU - Salomonis, Nathan

AU - Greene, Casey S.

AU - Frolova, Alina

AU - Henrickson, Sarah E.

AU - Wells, Andrew

AU - Pei, Liming

AU - Jaiswal, Jyoti K.

AU - Whitsett, Jeffrey

AU - Hamilton, Kathryn E.

AU - MacParland, Sonya A.

AU - Kelsen, Judith

AU - Heuckeroth, Robert O.

AU - Potter, S. Steven

AU - Vella, Laura A.

AU - Terry, Natalie A.

AU - Ghanem, Louis R.

AU - Kennedy, Benjamin C.

AU - Helbig, Ingo

AU - Sullivan, Kathleen E.

AU - Castelo-Soccio, Leslie

AU - Kreigstein, Arnold

AU - Herse, Florian

AU - Nawijn, Martijn C.

AU - Koppelman, Gerard H.

AU - Haendel, Melissa

AU - Harris, Nomi L.

AU - Rokita, Jo Lynne

AU - Zhang, Yuanchao

AU - Regev, Aviv

AU - Rozenblatt-Rosen, Orit

AU - Rood, Jennifer E.

AU - Tickle, Timothy L.

AU - Vento-Tormo, Roser

AU - Alimohamed, Saif

AU - Lek, Monkol

AU - Mar, Jessica C.

AU - Loomes, Kathleen M.

AU - Barrett, David M.

AU - Uapinyoying, Prech

AU - Beggs, Alan H.

AU - Agrawal, Pankaj B.

AU - Chen, Yi-Wen

AU - Muir, Amanda B.

AU - Garmire, Lana X.

AU - Snapper, Scott B.

AU - Nazarian, Javad

AU - Seeholzer, Steven H.

AU - Fazelinia, Hossein

AU - Singh, Larry N.

AU - Faryabi, Robert B.

AU - Raman, Pichai

AU - Dawany, Noor

AU - Xie, Hongbo Michael

AU - Devkota, Batsal

AU - Diskin, Sharon J.

AU - Anderson, Stewart A.

AU - Rappaport, Eric F.

AU - Peranteau, William

AU - Wikenheiser-Brokamp, Kathryn A.

AU - Teichmann, Sarah

AU - Wallace, Douglas

AU - Peng, Tao

AU - Ding, Yang-yang

AU - Kim, Man S.

AU - Xing, Yi

AU - Kong, Sek Won

AU - Bonnemann, Carsten G.

AU - Mandl, Kenneth D.

AU - White, Peter S.

PY - 2019/4/8

Y1 - 2019/4/8

N2 - Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan.

AB - Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan.

KW - INFLAMMATORY-BOWEL-DISEASE

KW - ACUTE LYMPHOBLASTIC-LEUKEMIA

KW - CHRONIC KIDNEY-DISEASE

KW - BILIARY ATRESIA

KW - SATELLITE CELLS

KW - GENE-EXPRESSION

KW - HEART-DISEASE

KW - RNA-SEQ

KW - SOMATIC MUTATIONS

KW - CHILDRENS HEALTH

U2 - 10.1016/j.devcel.2019.03.001

DO - 10.1016/j.devcel.2019.03.001

M3 - Review article

C2 - 30930166

VL - 49

SP - 10

EP - 29

JO - Developmental Cell

JF - Developmental Cell

SN - 1534-5807

IS - 1

ER -