Abstract
Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan.
Original language | English |
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Pages (from-to) | 10-29 |
Number of pages | 20 |
Journal | Developmental Cell |
Volume | 49 |
Issue number | 1 |
DOIs | |
Publication status | Published - 8-Apr-2019 |
Keywords
- INFLAMMATORY-BOWEL-DISEASE
- ACUTE LYMPHOBLASTIC-LEUKEMIA
- CHRONIC KIDNEY-DISEASE
- BILIARY ATRESIA
- SATELLITE CELLS
- GENE-EXPRESSION
- HEART-DISEASE
- RNA-SEQ
- SOMATIC MUTATIONS
- CHILDRENS HEALTH