Abstract
Objective: To construct a score that allows prediction of major depressive episode (MDE) persistence in individuals with MDE using determinants of persistence identified in previous research.
Method: Data were derived from 250 subjects from the general population with new MDE according to DSM-III-R. These subjects were recruited from the Netherlands Mental Health Survey and Incidence Study (NEMESIS), using the Composite International Diagnostic Interview. Determinants for persistence were transformed into a practical risk score using proportional hazards models and bootstrapping techniques.
Results: The risk of MDE persistence after 12 months was 23%. The score comprised measures of physical illness, social support, depression severity and recurrency, and duration of previous episodes. With increasing categories of these measures, the predicted risks increased from 7 to 40%.
Conclusion: We constructed the Persistence of Depression Score (PDS) showing reasonable performance. The PDS could be of importance in clinical practice to support treatment decisions.
| Original language | English |
|---|---|
| Pages (from-to) | 411-416 |
| Number of pages | 6 |
| Journal | Acta Psychiatrica Scandinavica |
| Volume | 114 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec-2006 |
Keywords
- depression
- prognosis
- risk assessment
- general population
- MENTAL-HEALTH SURVEY
- GENERAL-POPULATION
- MAJOR DEPRESSION
- PRIMARY-CARE
- NEMESIS
- EPISODES
- PSYCHOPATHOLOGY
- DISABILITY
- DISORDERS
- INTERVIEW
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