The phosphatase and tensin homologue deleted on chromosome 10 mediates radiosensitivity in head and neck cancer

W. J. Pattje, E. Schuuring, M. F. Mastik, L. Slagter-Menkema, M. L. Schrijvers, S. Alessi, B. F. A. M. van der Laan, J. L. N. Roodenburg, J. A. Langendijk, J. E. van der Wal*

*Corresponding author for this work

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Abstract

BACKGROUND: For locally advanced squamous cell carcinoma of the head and neck (HNSCC), the recurrence rate after surgery and postoperative radiotherapy is between 20 and 40%, and the 5- year overall survival rate is similar to 50%. Presently, no markers exist to accurately predict treatment outcome. Expression of proteins in the human epidermal growth factor receptor (EGFR) pathway has been reported as a prognostic marker in several types of cancer.

METHODS: The aim of this study was to investigate the prognostic value of proteins in the EGFR pathway in HNSCC. For this purpose, we collected surgically resected tissue of 140 locally advanced head and neck cancer patients, all treated with surgery and postoperative radiotherapy.

RESULTS: In a multivariate analysis, expression of the phosphatase and tensin homologue deleted on chromosome 10 (PTEN) was significantly related to worse locoregional control (LRC; HR: 2.2, 95% CI: 1.1-4.6; P = 0.03), independent of lymph node metastases (HR: 5.6, 95% CI: 1.2-27.4; P = 0.03) and extranodal spread (HR: 2.7; 95% CI: 1.2- 6.5; P = 0.02). In vitro clonogenic radiosensitivity assays confirmed that overexpression of PTEN resulted in increased radioresistance.

CONCLUSION: Our study is the first report showing that expression of PTEN mediates radiosensitivity in vitro and that increased expression in advanced HNSCC predicts worse LRC. British Journal of Cancer (2010) 102, 1778-1785. doi: 10.1038/sj.bjc.6605707 www.bjcancer.com Published online 25 May 2010 (C) 2010 Cancer Research UK

Original languageEnglish
Pages (from-to)1778-1785
Number of pages8
JournalBritish Jounal of Cancer
Volume102
Issue number12
DOIs
Publication statusPublished - 8-Jun-2010

Keywords

  • PTEN
  • HNSCC
  • radiosensitivity
  • locoregional control
  • EGFR pathway
  • GROWTH-FACTOR RECEPTOR
  • SQUAMOUS-CELL CARCINOMA
  • TISSUE MICROARRAY TECHNOLOGY
  • COPY NUMBER ALTERATIONS
  • PROGNOSTIC VALUE
  • PROSTATE-CANCER
  • PROTEIN EXPRESSION
  • SIGNALING PATHWAY
  • POOR-PROGNOSIS
  • TUMOR-CELLS

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