The plasma leptin/adiponectin ratio predicts first cardiovascular event in men: A prospective nested case-control study

Paul J.W.H. Kappelle, Robin P. F. Dullaart*, Andre P. van Beek, Hans L. Hillege, Bruce H. R. Wolffenbuttel

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

51 Citations (Scopus)
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Abstract

Objective: The plasma leptin/adiponectin (L/A) ratio has been proposed as a preferential marker of atherosclerosis susceptibility compared to leptin and adiponectin alone. We determined the extent to which the L/A ratio predicts incident cardiovascular disease (CVD) taking account of clinical risk factors, microalbuminuria, the total cholesterol/HDL cholesterol (TC/HDL-C ratio), triglycerides, high sensitive C-reactive protein (hs-CRP) and insulin sensitivity (homeostasis model assessment (HOMA(ir))).

Methods: A community-based prospective nested case-control study was carried out in 103 non-diabetic men who developed a first cardiovascular event (cases) and 106 male control subjects (no clinically manifest CVD and no lipid lowering drug use at baseline; median follow-up of 3.0 and 10.5 years, respectively). Plasma leptin, adiponectin, the leptin/adipnectin (L/A) ratio, as well as hs-CRP, HOMA(ir) and the TC/HDL-C ratio were determined at baseline.

Results: Plasma leptin levels and the L/A ratio were higher in cases vs. controls (p=0.002 for both), but the difference in adiponectin was not significant (p=0.10). Age-adjusted incident CVD was associated with plasma leptin, adiponectin and the L/A ratio (p=0.045 to p=0.001). The relationships of incident CVD with plasma leptin (p=0.19) and adiponectin (p=0.073) lost statistical significance after additional adjustment for smoking, waist circumference, hypertension, microalbuminuria, the TC/HDL-C ratio, hs-CRP and HOMA(ir). In this fully adjusted analysis, the L/A ratio remained predictive of incident CVD (hazard ratio: 1.40 (95% CI 1.05-1.87), p=0.024).

Conclusion: This study suggests that the L/A ratio may be a preferential marker of a first cardiovascular event in men compared to plasma leptin and adiponectin levels alone. (C) 2012 European Federation of Internal Medicine. Published by Elsevier B. V. All rights reserved.

Original languageEnglish
Pages (from-to)755-759
Number of pages5
JournalEuropean Journal of Internal Medicine
Volume23
Issue number8
DOIs
Publication statusPublished - Dec-2012

Keywords

  • Adiponectin
  • Cardiovascular disease
  • Leptin
  • Leptin/adiponectin ratio
  • Total cholesterol/HDL cholesterol ratio
  • INTIMA-MEDIA THICKNESS
  • CORONARY-HEART-DISEASE
  • C-REACTIVE PROTEIN
  • LEPTIN ADIPONECTIN RATIO
  • TYPE-2 DIABETES-MELLITUS
  • METABOLIC SYNDROME
  • ADIPOSE-TISSUE
  • RISK
  • MARKERS
  • MICROALBUMINURIA

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