The prebiotic concept and human health: a changing landscape with riboflavin as a novel prebiotic candidate?

R. E. Steinert*, Mehdi Sadaghian, H. J. M. Harmsen, P. Weber

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)

Abstract

Emerging evidence suggests that the gut microbiota has a critical role in both the maintenance of human health and the pathogenesis of many diseases. Modifying the colonic microbiota using functional foods has attracted significant research effort and product development. The pioneering concept of prebiotics, as introduced by Gibson and Roberfroid in the 1990s, emphasized the importance of diet in the modulation of the gut microbiota and its relationships to human health. Increasing knowledge of the intestinal microbiota now suggests a more comprehensive definition. This paper briefly reviews the basics of the prebiotic concept with a discussion of recent attempts to refine the concept to open the door for novel prebiotic food ingredients, such as polyphenols, minerals and vitamins.

Original languageEnglish
Pages (from-to)1348-1353
Number of pages6
JournalEuropean Journal of Clinical Nutrition
Volume70
Issue number12
DOIs
Publication statusPublished - Dec-2016

Keywords

  • HUMAN COLONIC MICROBIOTA
  • HIGH-DOSE RIBOFLAVIN
  • HIGH-FAT DIET
  • GUT MICROBIOTA
  • FAECALIBACTERIUM-PRAUSNITZII
  • INTESTINAL MICROBIOTA
  • OBESE MICE
  • CLOSTRIDIUM-DIFFICILE
  • MIGRAINE PROPHYLAXIS
  • INSULIN SENSITIVITY

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