THE PROGNOSTIC-SIGNIFICANCE OF ACCUMULATION OF P53 PROTEIN IN STAGE-III NON-SMALL-CELL LUNG-CANCER TREATED BY RADIOTHERAPY

JA LANGENDIJK*, FBJM THUNNISSEN, RJS LAMERS, JMA DEJONG, GPM TENVELDE, EFM WOUTERS

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Scopus)

Abstract

In the present study the prognostic significance of accumulation of nuclear p53 protein on survival and freedom from local progression was investigated. Formalin-fixed, paraffin-embedded sections obtained by bronchoscopy or mediastinoscopy were used to examine the expression of nuclear p53 protein using immunohistochemistry. In 37 cases (57%), overexpression of the p53 protein was detected. No relation was found between p53 expression and other pretreatment variables. Response to radiotherapy was found in 11 p53-negative cases (65%) versus 10 p53-positive cases (42%). Freedom from local progression was significantly better in the p53-negative cases as compared with the p53-positive cases. The p53-negative cases who responded to radiotherapy showed an excellent freedom from local progression rate after 2 years of 100%, whereas all p53-positive cases without response to radiotherapy showed local progression within 24 months. Overall survival between p53-negative and -positive cases did not differ, however the disease-specific survival was found to be worse in the p53-positive cases as compared to the negative cases (median survival 8.4 vs, 14.4 months (P <0.05)). No correlation was found between p53 expression and the frequency of distant metastases. In conclusion, the results of this study suggest that p53 protein expression may be of prognostic value on freedom from local progression in non-small cell lung carcinoma.

Original languageEnglish
Pages (from-to)218-224
Number of pages7
JournalRadiotherapy and Oncology
Volume36
Issue number3
DOIs
Publication statusPublished - Sep-1995
Externally publishedYes

Keywords

  • NON-SMALL CELL LUNG CANCER
  • P53 EXPRESSION
  • RADIOTHERAPY
  • RADIOSENSITIVITY
  • TUMOR-SUPPRESSOR GENE
  • WILD-TYPE
  • RAS MUTATIONS
  • DNA-DAMAGE
  • APOPTOSIS
  • TRANSCRIPTION
  • EXPRESSION
  • RADIATION
  • CARCINOMA
  • SURVIVAL

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