The Progress and Prospect of Zeolitic Imidazolate Frameworks in Cancer Therapy, Antibacterial Activity, and Biomineralization

Aziz Maleki*, Mohammad-Ali Shahbazi, Vajiheh Alinezhad, Hélder A. Santos*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

24 Citations (Scopus)
3 Downloads (Pure)

Abstract

The progressive development of zeolitic imidazolate frameworks (ZIFs), as a subfamily of metal‐organic frameworks (MOFs), and their unique features, including tunable pore size, large surface area, high thermal stability, and biodegradability/biocompatibility, have made them attractive in the field of biomedicine, especially for drug delivery and biomineralization applications. The high porosity of ZIFs gives them the opportunity for encapsulating a high amount of therapeutic drugs, proteins, imaging cargos, or a combination of them to construct advanced multifunctional drug delivery systems (DDSs) with combined therapeutic and imaging capabilities. This review summarizes recent strategies on the design and fabrication of ZIF‐based nansystems and their exploration in the biomedical field. First, recent developments for the adjustment of particle size, functionality, and morphology of ZIFs are discussed, which are important for achieving optimized therapeutic/theranostic nanosystems. Second, recent trends on the application of ZIF nanocarriers for the loading of diverse cargos, including anticancer medicines, antibiotic drugs, enzymes, proteins, photosensitizers, as well as imaging and photothermal agents, are investigated in order to understand how multifunctional DDSs can be designed based on the ZIF nanoparticles to treat different diseases, such as cancer and infection. Finally, prospects on the future research direction and applications of ZIF‐based nanomedicines are discussed.
Original languageEnglish
Article number2000248
Number of pages42
JournalAdvanced healthcare materials
Volume9
Issue number12
DOIs
Publication statusPublished - Jun-2020
Externally publishedYes

Keywords

  • CORE-SHELL NANOPARTICLES
  • FACILE SYNTHESIS
  • FAVORABLE BIOCOMPATIBILITY
  • HOLLOW MESOPOROUS SILICA
  • METAL-ORGANIC FRAMEWORKS
  • ONE-POT SYNTHESIS
  • PHOTODYNAMIC THERAPY
  • RESPONSIVE DRUG-DELIVERY
  • WATER-BASED SYNTHESIS
  • ZIF nanoparticles
  • ZIF-8 NANOPARTICLES
  • antibacterial therapies
  • biomineralization
  • cancer therapies
  • metal-organic frameworks
  • 317 Pharmacy
  • 3111 Biomedicine
  • 221 Nano-technology

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