The progress in corneal translational medicine

Zoe Hancox, Saeed Heidari Keshel, Safiyya Yousaf, Morvarid Saelnasab, Mohammad-Ali Shahbazi, Farshid Sefat*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

5 Citations (Scopus)
3 Downloads (Pure)

Abstract

Cornea tissue is in high demand by tissue donation centres globally, and thus tissue engineering cornea, which is the main topic of corneal translational medicine, can serve as a limitless alternative to a donated human cornea tissue. Tissue engineering aims to produce solutions to the challenges associated with conventional cornea tissue, including transplantation and use of human amniotic membrane (HAM), which have issues with storage and immune rejection in patients. Accordingly, by carefully selecting biomaterials and fabrication methods to produce these therapeutic tissues, the demand for cornea tissue can be met, with an improved healing outcome for recipients with less associated harmful risks. In this review paper, we aim to present the recent advancements in the research and clinical applications of cornea tissue, applications including biomaterial selection, fabrication methods, scaffold structure, cellular response to these scaffolds, and future advancements of these techniques.
Original languageEnglish
Pages (from-to)6469-6504
Number of pages36
JournalBiomaterials Science
Volume8
Issue number23
DOIs
Publication statusPublished - 7-Dec-2020
Externally publishedYes

Keywords

  • MESENCHYMAL STEM-CELLS
  • MUCOSAL EPITHELIAL TRANSPLANTATION
  • OCULAR SURFACE RECONSTRUCTION
  • HEPATOCYTE GROWTH-FACTOR
  • EX-VIVO EXPANSION
  • BONE-MARROW
  • EXTRACELLULAR-MATRIX
  • AMNIOTIC MEMBRANE
  • IN-VITRO
  • CHONDROITIN SULFATE
  • 318 Medical biotechnology
  • 317 Pharmacy

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